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A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.
Ahmed Z, Cooper J, Murray TK, Garn K, McNaughton E, Clarke H, Parhizkar S, Ward MA, Cavallini A, Jackson S, Bose S, Clavaguera F, Tolnay M, Lavenir I, Goedert M, Hutton ML, O'Neill MJ. Ahmed Z, et al. Acta Neuropathol. 2014 May;127(5):667-83. doi: 10.1007/s00401-014-1254-6. Epub 2014 Feb 16. Acta Neuropathol. 2014. PMID: 24531916 Free PMC article.
Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: evidence against the role of tau pathology to impair vascular health in Alzheimer's disease.
Wells JA, Holmes HE, O'Callaghan JM, Colgan N, Ismail O, Fisher EM, Siow B, Murray TK, Schwarz AJ, O'Neill MJ, Collins EC, Lythgoe MF. Wells JA, et al. J Cereb Blood Flow Metab. 2015 Mar;35(3):359-62. doi: 10.1038/jcbfm.2014.224. Epub 2014 Dec 17. J Cereb Blood Flow Metab. 2015. PMID: 25515210 Free PMC article.
Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model.
Wang H, Li Y, Ryder JW, Hole JT, Ebert PJ, Airey DC, Qian HR, Logsdon B, Fisher A, Ahmed Z, Murray TK, Cavallini A, Bose S, Eastwood BJ, Collier DA, Dage JL, Miller BB, Merchant KM, O'Neill MJ, Demattos RB. Wang H, et al. Mol Neurodegener. 2018 Dec 17;13(1):65. doi: 10.1186/s13024-018-0296-y. Mol Neurodegener. 2018. PMID: 30558641 Free PMC article.
Transcriptional Signatures of Tau and Amyloid Neuropathology.
Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, Moore K, O'Neill P, Lunnon K, Collier DA, Ahmed Z, O'Neill MJ, Mill J. Castanho I, et al. Cell Rep. 2020 Feb 11;30(6):2040-2054.e5. doi: 10.1016/j.celrep.2020.01.063. Cell Rep. 2020. PMID: 32049030 Free PMC article.
Impaired glymphatic function and clearance of tau in an Alzheimer's disease model.
Harrison IF, Ismail O, Machhada A, Colgan N, Ohene Y, Nahavandi P, Ahmed Z, Fisher A, Meftah S, Murray TK, Ottersen OP, Nagelhus EA, O'Neill MJ, Wells JA, Lythgoe MF. Harrison IF, et al. Brain. 2020 Aug 1;143(8):2576-2593. doi: 10.1093/brain/awaa179. Brain. 2020. PMID: 32705145 Free PMC article.
Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease.
O'Callaghan J, Holmes H, Powell N, Wells JA, Ismail O, Harrison IF, Siow B, Johnson R, Ahmed Z, Fisher A, Meftah S, O'Neill MJ, Murray TK, Collins EC, Shmueli K, Lythgoe MF. O'Callaghan J, et al. Neuroimage. 2017 Oct 1;159:334-345. doi: 10.1016/j.neuroimage.2017.08.003. Epub 2017 Aug 4. Neuroimage. 2017. PMID: 28797738 Free PMC article.
273 results