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Synthesis and Pharmacological Evaluation of Novel Adenine-Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents.
Lougiakis N, Papapetropoulos A, Gikas E, Toumpas S, Efentakis P, Wedmann R, Zoga A, Zhou Z, Iliodromitis EK, Skaltsounis AL, Filipovic MR, Pouli N, Marakos P, Andreadou I. Lougiakis N, et al. Among authors: wedmann r. J Med Chem. 2016 Mar 10;59(5):1776-90. doi: 10.1021/acs.jmedchem.5b01223. Epub 2016 Feb 8. J Med Chem. 2016. PMID: 26809888
Working with "H2S": facts and apparent artifacts.
Wedmann R, Bertlein S, Macinkovic I, Böltz S, Miljkovic JLj, Muñoz LE, Herrmann M, Filipovic MR. Wedmann R, et al. Nitric Oxide. 2014 Sep 15;41:85-96. doi: 10.1016/j.niox.2014.06.003. Epub 2014 Jun 13. Nitric Oxide. 2014. PMID: 24932545
Biosynthesis and Reactivity of Cysteine Persulfides in Signaling.
Yadav PK, Martinov M, Vitvitsky V, Seravalli J, Wedmann R, Filipovic MR, Banerjee R. Yadav PK, et al. Among authors: wedmann r. J Am Chem Soc. 2016 Jan 13;138(1):289-99. doi: 10.1021/jacs.5b10494. Epub 2015 Dec 28. J Am Chem Soc. 2016. PMID: 26667407 Free PMC article.
Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation.
Wedmann R, Onderka C, Wei S, Szijártó IA, Miljkovic JL, Mitrovic A, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipovic MR. Wedmann R, et al. Chem Sci. 2016 May 25;7(5):3414-3426. doi: 10.1039/c5sc04818d. Epub 2016 Feb 19. Chem Sci. 2016. PMID: 27170841 Free PMC article.