ThreaDNA: predicting DNA mechanics' contribution to sequence selectivity of proteins along whole genomes.
Cevost J, Vaillant C, Meyer S, Rost B.
Cevost J, et al. Among authors: meyer s.
Bioinformatics. 2018 Feb 15;34(4):609-616. doi: 10.1093/bioinformatics/btx634.
Bioinformatics. 2018.
PMID: 29444234
MOTIVATION: Many DNA-binding proteins recognize their target sequences indirectly, by sensing DNA's response to mechanical distortion. ThreaDNA estimates this response based on high-resolution structures of the protein-DNA complex of interest. ...AVAILABILITY AND IMPLEMENT …
MOTIVATION: Many DNA-binding proteins recognize their target sequences indirectly, by sensing DNA's response to mechanical distortion …