Rose KA - Search Results

1

Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity.

Rose KA, Holman NS, Green AM, Andersen ME, LeCluyse EL. Rose KA, et al. J Pharm Sci. 2016 Feb;105(2):950-964. doi: 10.1016/S0022-3549(15)00192-6. J Pharm Sci. 2016. PMID: 26869439 Free PMC article.

2

Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury.

Holman NS, Church RJ, Nautiyal M, Rose KA, Thacker SE, Otieno MA, Wolf KK, LeCluyse E, Watkins PB, Mosedale M. Holman NS, et al. Among authors: rose ka. Toxicol Sci. 2019 Aug 1;170(2):499-508. doi: 10.1093/toxsci/kfz112. Toxicol Sci. 2019. PMID: 31093666 Free PMC article.

3

Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABAA receptor antagonist NP260.

Harrill AH, Eaddy JS, Rose K, Cullen JM, Ramanathan L, Wanaski S, Collins S, Ho Y, Watkins PB, Lecluyse EL. Harrill AH, et al. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):131-7. doi: 10.1016/j.taap.2014.03.015. Epub 2014 Mar 31. Toxicol Appl Pharmacol. 2014. PMID: 24699182

4

Bioactivation and toxicity of acetaminophen in a rat hepatocyte micropatterned coculture system.

Ukairo O, McVay M, Krzyzewski S, Aoyama S, Rose K, Andersen ME, Khetani SR, Lecluyse EL. Ukairo O, et al. J Biochem Mol Toxicol. 2013 Oct;27(10):471-8. doi: 10.1002/jbt.21512. Epub 2013 Aug 5. J Biochem Mol Toxicol. 2013. PMID: 23918466

5

Long-term stability of primary rat hepatocytes in micropatterned cocultures.

Ukairo O, Kanchagar C, Moore A, Shi J, Gaffney J, Aoyama S, Rose K, Krzyzewski S, McGeehan J, Andersen ME, Khetani SR, Lecluyse EL. Ukairo O, et al. J Biochem Mol Toxicol. 2013 Mar;27(3):204-12. doi: 10.1002/jbt.21469. Epub 2013 Jan 11. J Biochem Mol Toxicol. 2013. PMID: 23315828

6

Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.

Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW. Sahi J, et al. Among authors: rose ka. Drug Metab Dispos. 2003 Apr;31(4):439-46. doi: 10.1124/dmd.31.4.439. Drug Metab Dispos. 2003. PMID: 12642470

7

Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo.

Sahi J, Stern RH, Milad MA, Rose KA, Gibson G, Zheng X, Stilgenbauer L, Sadagopan N, Jolley S, Gilbert D, LeCluyse EL. Sahi J, et al. Among authors: rose ka. Drug Metab Dispos. 2004 Dec;32(12):1370-6. doi: 10.1124/dmd.104.000208. Epub 2004 Aug 27. Drug Metab Dispos. 2004. PMID: 15333513

8

Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor.

Sahi J, Milad MA, Zheng X, Rose KA, Wang H, Stilgenbauer L, Gilbert D, Jolley S, Stern RH, LeCluyse EL. Sahi J, et al. Among authors: rose ka. J Pharmacol Exp Ther. 2003 Sep;306(3):1027-34. doi: 10.1124/jpet.103.050526. Epub 2003 May 23. J Pharmacol Exp Ther. 2003. PMID: 12766253

9

Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats.

Kostrubsky VE, Strom SC, Hanson J, Urda E, Rose K, Burliegh J, Zocharski P, Cai H, Sinclair JF, Sahi J. Kostrubsky VE, et al. Toxicol Sci. 2003 Nov;76(1):220-8. doi: 10.1093/toxsci/kfg217. Epub 2003 Aug 27. Toxicol Sci. 2003. PMID: 12944587

10

Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes.

Wen YH, Sahi J, Urda E, Kulkarni S, Rose K, Zheng X, Sinclair JF, Cai H, Strom SC, Kostrubsky VE. Wen YH, et al. Drug Metab Dispos. 2002 Sep;30(9):977-84. doi: 10.1124/dmd.30.9.977. Drug Metab Dispos. 2002. PMID: 12167562

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