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Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation.
Mol Carcinog. 2017 Jan;56(1):49-61. doi: 10.1002/mc.22472. Epub 2016 Feb 15.
Mol Carcinog. 2017.
PMID: 26878440
Free PMC article.
The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation.
Aronchik I, Kundu A, Quirit JG, Firestone GL.
Aronchik I, et al. Among authors: quirit jg.
Mol Cancer Res. 2014 Nov;12(11):1621-1634. doi: 10.1158/1541-7786.MCR-14-0018. Epub 2014 Jul 9.
Mol Cancer Res. 2014.
PMID: 25009292
Free PMC article.
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Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.
Quirit JG, Lavrenov SN, Poindexter K, Xu J, Kyauk C, Durkin KA, Aronchik I, Tomasiak T, Solomatin YA, Preobrazhenskaya MN, Firestone GL.
Quirit JG, et al.
Biochem Pharmacol. 2017 Mar 1;127:13-27. doi: 10.1016/j.bcp.2016.12.007. Epub 2016 Dec 12.
Biochem Pharmacol. 2017.
PMID: 27979631
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Insights into Mycoplasma genitalium metabolism revealed by the structure of MG289, an extracytoplasmic thiamine binding lipoprotein.
Sippel KH, Venkatakrishnan B, Boehlein SK, Sankaran B, Quirit JG, Govindasamy L, Agbandje-McKenna M, Goodison S, Rosser CJ, McKenna R.
Sippel KH, et al. Among authors: quirit jg.
Proteins. 2011 Feb;79(2):528-36. doi: 10.1002/prot.22900.
Proteins. 2011.
PMID: 21117240
Free PMC article.
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Cloning, expression, purification, crystallization and preliminary X-ray analysis of Mycoplasma genitalium protein MG289.
Sippel KH, Boehlein SK, Sakai Y, Quirit JG, Agbandje-McKenna M, Rosser CJ, McKenna R.
Sippel KH, et al. Among authors: quirit jg.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Sep 1;65(Pt 9):910-2. doi: 10.1107/S1744309109030565. Epub 2009 Aug 22.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009.
PMID: 19724130
Free PMC article.
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