Fraser NJ - Search Results

1

Conformational Disorganization within the Active Site of a Recently Evolved Organophosphate Hydrolase Limits Its Catalytic Efficiency.

Mabbitt PD, Correy GJ, Meirelles T, Fraser NJ, Coote ML, Jackson CJ. Mabbitt PD, et al. Among authors: fraser nj. Biochemistry. 2016 Mar 8;55(9):1408-17. doi: 10.1021/acs.biochem.5b01322. Epub 2016 Feb 26. Biochemistry. 2016. PMID: 26881849

2

Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography.

Correy GJ, Carr PD, Meirelles T, Mabbitt PD, Fraser NJ, Weik M, Jackson CJ. Correy GJ, et al. Among authors: fraser nj. Structure. 2016 Jun 7;24(6):977-87. doi: 10.1016/j.str.2016.04.009. Epub 2016 May 19. Structure. 2016. PMID: 27210287 Free article.

3

Structure of an Insecticide Sequestering Carboxylesterase from the Disease Vector Culex quinquefasciatus: What Makes an Enzyme a Good Insecticide Sponge?

Hopkins DH, Fraser NJ, Mabbitt PD, Carr PD, Oakeshott JG, Jackson CJ. Hopkins DH, et al. Among authors: fraser nj. Biochemistry. 2017 Oct 17;56(41):5512-5525. doi: 10.1021/acs.biochem.7b00774. Epub 2017 Sep 29. Biochemistry. 2017. PMID: 28929747

4

Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability.

Fraser NJ, Liu JW, Mabbitt PD, Correy GJ, Coppin CW, Lethier M, Perugini MA, Murphy JM, Oakeshott JG, Weik M, Jackson CJ. Fraser NJ, et al. J Mol Biol. 2016 Jun 5;428(11):2359-2371. doi: 10.1016/j.jmb.2016.03.014. Epub 2016 Mar 22. J Mol Biol. 2016. PMID: 27016206

5

Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila.

Younus F, Fraser NJ, Coppin CW, Liu JW, Correy GJ, Chertemps T, Pandey G, Maïbèche M, Jackson CJ, Oakeshott JG. Younus F, et al. Among authors: fraser nj. Sci Rep. 2017 Apr 10;7:46188. doi: 10.1038/srep46188. Sci Rep. 2017. PMID: 28393888 Free PMC article.

6

Evolutionary expansion of the amidohydrolase superfamily in bacteria in response to the synthetic compounds molinate and diuron.

Sugrue E, Fraser NJ, Hopkins DH, Carr PD, Khurana JL, Oakeshott JG, Scott C, Jackson CJ. Sugrue E, et al. Among authors: fraser nj. Appl Environ Microbiol. 2015 Apr;81(7):2612-24. doi: 10.1128/AEM.04016-14. Epub 2015 Jan 30. Appl Environ Microbiol. 2015. PMID: 25636851 Free PMC article.

7

Total Syntheses of the 3H-Pyrrolo[2,3-c]quinolone-Containing Alkaloids Marinoquinolines A-F, K, and Aplidiopsamine A Using a Palladium-Catalyzed Ullmann Cross-Coupling/Reductive Cyclization Pathway.

Bolte B, Bryan CS, Sharp PP, Sayyahi S, Rihouey C, Kendrick A, Lan P, Banwell MG, Jackson CJ, Fraser NJ, Willis AC, Ward JS. Bolte B, et al. Among authors: fraser nj. J Org Chem. 2020 Jan 17;85(2):650-663. doi: 10.1021/acs.joc.9b02725. Epub 2019 Dec 18. J Org Chem. 2020. PMID: 31742404

8

Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6.

Howie J, Tulloch LB, Brown E, Reilly L, Ashford FB, Kennedy J, Wypijewski KJ, Aughton KL, Mak JKC, Shattock MJ, Fraser NJ, Fuller W. Howie J, et al. Among authors: fraser nj. Cell Rep. 2024 Feb 27;43(2):113679. doi: 10.1016/j.celrep.2024.113679. Epub 2024 Jan 17. Cell Rep. 2024. PMID: 38236777 Free article.

9

Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial.

Aronne LJ, Sattar N, Horn DB, Bays HE, Wharton S, Lin WY, Ahmad NN, Zhang S, Liao R, Bunck MC, Jouravskaya I, Murphy MA; SURMOUNT-4 Investigators. Aronne LJ, et al. JAMA. 2024 Jan 2;331(1):38-48. doi: 10.1001/jama.2023.24945. JAMA. 2024. PMID: 38078870 Free PMC article. Clinical Trial.

10

Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.

Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, Mao H, Zhang S, Ahmad NN, Bunck MC, Benabbad I, Zhang XM; SURMOUNT-2 investigators. Garvey WT, et al. Lancet. 2023 Aug 19;402(10402):613-626. doi: 10.1016/S0140-6736(23)01200-X. Epub 2023 Jun 26. Lancet. 2023. PMID: 37385275 Clinical Trial.

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