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Page 1
New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.
Pajk S, Živec M, Šink R, Sosič I, Neu M, Chung CW, Martínez-Hoyos M, Pérez-Herrán E, Álvarez-Gómez D, Álvarez-Ruíz E, Mendoza-Losana A, Castro-Pichel J, Barros D, Ballell-Pages L, Young RJ, Convery MA, Encinas L, Gobec S. Pajk S, et al. Among authors: alvarez gomez d. Eur J Med Chem. 2016 Apr 13;112:252-257. doi: 10.1016/j.ejmech.2016.02.008. Epub 2016 Feb 8. Eur J Med Chem. 2016. PMID: 26900657
Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA.
Encinas L, O'Keefe H, Neu M, Remuiñán MJ, Patel AM, Guardia A, Davie CP, Pérez-Macías N, Yang H, Convery MA, Messer JA, Pérez-Herrán E, Centrella PA, Alvarez-Gómez D, Clark MA, Huss S, O'Donovan GK, Ortega-Muro F, McDowell W, Castañeda P, Arico-Muendel CC, Pajk S, Rullás J, Angulo-Barturen I, Alvarez-Ruíz E, Mendoza-Losana A, Ballell Pages L, Castro-Pichel J, Evindar G. Encinas L, et al. Among authors: alvarez gomez d. J Med Chem. 2014 Feb 27;57(4):1276-88. doi: 10.1021/jm401326j. Epub 2014 Feb 5. J Med Chem. 2014. PMID: 24450589
Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis.
Šink R, Sosič I, Živec M, Fernandez-Menendez R, Turk S, Pajk S, Alvarez-Gomez D, Lopez-Roman EM, Gonzales-Cortez C, Rullas-Triconado J, Angulo-Barturen I, Barros D, Ballell-Pages L, Young RJ, Encinas L, Gobec S. Šink R, et al. Among authors: alvarez gomez d. J Med Chem. 2015 Jan 22;58(2):613-24. doi: 10.1021/jm501029r. Epub 2014 Dec 29. J Med Chem. 2015. PMID: 25517015
Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery.
Rebollo-Lopez MJ, Lelièvre J, Alvarez-Gomez D, Castro-Pichel J, Martínez-Jiménez F, Papadatos G, Kumar V, Colmenarejo G, Mugumbate G, Hurle M, Barroso V, Young RJ, Martinez-Hoyos M, González del Río R, Bates RH, Lopez-Roman EM, Mendoza-Losana A, Brown JR, Alvarez-Ruiz E, Marti-Renom MA, Overington JP, Cammack N, Ballell L, Barros-Aguire D. Rebollo-Lopez MJ, et al. Among authors: alvarez gomez d. PLoS One. 2015 Dec 7;10(12):e0142293. doi: 10.1371/journal.pone.0142293. eCollection 2015. PLoS One. 2015. PMID: 26642067 Free PMC article.
Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.
Martínez-Hoyos M, Perez-Herran E, Gulten G, Encinas L, Álvarez-Gómez D, Alvarez E, Ferrer-Bazaga S, García-Pérez A, Ortega F, Angulo-Barturen I, Rullas-Trincado J, Blanco Ruano D, Torres P, Castañeda P, Huss S, Fernández Menéndez R, González Del Valle S, Ballell L, Barros D, Modha S, Dhar N, Signorino-Gelo F, McKinney JD, García-Bustos JF, Lavandera JL, Sacchettini JC, Jimenez MS, Martín-Casabona N, Castro-Pichel J, Mendoza-Losana A. Martínez-Hoyos M, et al. Among authors: alvarez gomez d. EBioMedicine. 2016 Jun;8:291-301. doi: 10.1016/j.ebiom.2016.05.006. Epub 2016 May 8. EBioMedicine. 2016. PMID: 27428438 Free PMC article.
Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.
Ballell L, Bates RH, Young RJ, Alvarez-Gomez D, Alvarez-Ruiz E, Barroso V, Blanco D, Crespo B, Escribano J, González R, Lozano S, Huss S, Santos-Villarejo A, Martín-Plaza JJ, Mendoza A, Rebollo-Lopez MJ, Remuiñan-Blanco M, Lavandera JL, Pérez-Herran E, Gamo-Benito FJ, García-Bustos JF, Barros D, Castro JP, Cammack N. Ballell L, et al. Among authors: alvarez gomez d. ChemMedChem. 2013 Feb;8(2):313-21. doi: 10.1002/cmdc.201200428. Epub 2013 Jan 10. ChemMedChem. 2013. PMID: 23307663 Free PMC article.
Tarsal tunnel syndrome: Clinical-imaging analysis of a case series.
Vargas Gallardo F, Álvarez Gómez D, Bastías Soto C, Henríquez Sazo H, Lagos Sepúlveda L, Vera Salas R, Díaz Morales J, Fernández Comber S. Vargas Gallardo F, et al. Among authors: alvarez gomez d. Rev Esp Cir Ortop Traumatol. 2022 Jan-Feb;66(1):23-28. doi: 10.1016/j.recot.2020.11.005. Epub 2021 May 2. Rev Esp Cir Ortop Traumatol. 2022. PMID: 33947645 Free article. English, Spanish.
CT imaging of complications of aortic intramural hematoma: a pictorial essay.
Herrán FL, Bang TJ, Restauri N, Suby-Long T, Alvarez Gómez DI, Sachs PB, Vargas D. Herrán FL, et al. Among authors: alvarez gomez di. Diagn Interv Radiol. 2018 Nov;24(6):342-347. doi: 10.5152/dir.2018.17261. Diagn Interv Radiol. 2018. PMID: 30373726 Free PMC article. Review.
Hamartomas from head to toe: an imaging overview.
Leiter Herrán F, Restrepo CS, Alvarez Gómez DI, Suby-Long T, Ocazionez D, Vargas D. Leiter Herrán F, et al. Among authors: alvarez gomez di. Br J Radiol. 2017 Mar;90(1071):20160607. doi: 10.1259/bjr.20160607. Epub 2016 Dec 12. Br J Radiol. 2017. PMID: 27936889 Free PMC article. Review.