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Acetylation of C/EBPα inhibits its granulopoietic function.
Bararia D, Kwok HS, Welner RS, Numata A, Sárosi MB, Yang H, Wee S, Tschuri S, Ray D, Weigert O, Levantini E, Ebralidze AK, Gunaratne J, Tenen DG. Bararia D, et al. Among authors: kwok hs. Nat Commun. 2016 Mar 23;7:10968. doi: 10.1038/ncomms10968. Nat Commun. 2016. PMID: 27005833 Free PMC article.
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.
Numata A, Kwok HS, Zhou QL, Li J, Tirado-Magallanes R, Angarica VE, Hannah R, Park J, Wang CQ, Krishnan V, Rajagopalan D, Zhang Y, Zhou S, Welner RS, Osato M, Jha S, Bohlander SK, Göttgens B, Yang H, Benoukraf T, Lough JW, Bararia D, Tenen DG. Numata A, et al. Among authors: kwok hs. Blood. 2020 Oct 8;136(15):1735-1747. doi: 10.1182/blood.2019001279. Blood. 2020. PMID: 32542325 Free PMC article.
TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter.
Rajagopalan D, Pandey AK, Xiuzhen MC, Lee KK, Hora S, Zhang Y, Chua BH, Kwok HS, Bhatia SS, Deng LW, Tenen DG, Kappei D, Jha S. Rajagopalan D, et al. Among authors: kwok hs. PLoS Pathog. 2017 Oct 18;13(10):e1006681. doi: 10.1371/journal.ppat.1006681. eCollection 2017 Oct. PLoS Pathog. 2017. PMID: 29045464 Free PMC article.
Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility.
Leong DT, Lim J, Goh X, Pratap J, Pereira BP, Kwok HS, Nathan SS, Dobson JR, Lian JB, Ito Y, Voorhoeve PM, Stein GS, Salto-Tellez M, Cool SM, van Wijnen AJ. Leong DT, et al. Among authors: kwok hs. Breast Cancer Res. 2010;12(5):R89. doi: 10.1186/bcr2762. Epub 2010 Oct 28. Breast Cancer Res. 2010. PMID: 21029421 Free PMC article.
Asymmetric Engagement of Dimeric CRL3 KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes.
Yeo MJ, Zhang O, Xie X, Nam E, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen NJ, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat IA, Takahashi M, Waterbury AL, Barone M, Mattevi A, Bar-Peled L, Cole PA, Mazitschek R, Liau BB, Zheng N. Yeo MJ, et al. Among authors: kwok hs. bioRxiv [Preprint]. 2024 May 14:2024.05.14.593897. doi: 10.1101/2024.05.14.593897. bioRxiv. 2024. PMID: 38798619 Free PMC article. Preprint.
KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes.
Xie X, Zhang O, Yeo MJR, Lee C, Harry SA, Paul L, Li Y, Payne NC, Nam E, Kwok HS, Jiang H, Mao H, Hadley JL, Lin H, Batts M, Gosavi PM, D'Angiolella V, Cole PA, Mazitschek R, Northcott PA, Zheng N, Liau BB. Xie X, et al. Among authors: kwok hs. bioRxiv [Preprint]. 2024 May 14:2024.05.14.593970. doi: 10.1101/2024.05.14.593970. bioRxiv. 2024. PMID: 38798357 Free PMC article. Preprint.
131 results