Identification and optimization of nitrophenolic analogues as dopamine metabolic enzyme inhibitors for the treatment of Parkinson's disease.
Zou M, Wu Y, Lan Y, Xie H, Sun H, Liu W, Feng F, Jiang X.
Zou M, et al.
Bioorg Chem. 2024 May 23;148:107488. doi: 10.1016/j.bioorg.2024.107488. Online ahead of print.
Bioorg Chem. 2024.
PMID: 38797066
Simultaneous inhibition of the two key dopamine metabolic enzymes, catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAO-B), could potentially be a breakthrough in achieving clinical efficacy. ...
Simultaneous inhibition of the two key dopamine metabolic enzymes, catechol-O-methyltransferase (COMT) and monoamine oxidase B …