Carragher NO - Search Results

1

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A. Fraser C, et al. Among authors: carragher no. J Med Chem. 2016 May 26;59(10):4697-710. doi: 10.1021/acs.jmedchem.6b00065. Epub 2016 May 4. J Med Chem. 2016. PMID: 27115835 Free PMC article.

2

Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.

Carragher NO, Fincham VJ, Riley D, Frame MC. Carragher NO, et al. J Biol Chem. 2001 Feb 9;276(6):4270-5. doi: 10.1074/jbc.M008972200. Epub 2000 Nov 7. J Biol Chem. 2001. PMID: 11069922 Free article.

3

The mechanism of cell cycle regulation by v-Src.

Riley D, Carragher NO, Frame MC, Wyke JA. Riley D, et al. Among authors: carragher no. Oncogene. 2001 Sep 20;20(42):5941-50. doi: 10.1038/sj.onc.1204826. Oncogene. 2001. PMID: 11593401

4

v-Src-induced modulation of the calpain-calpastatin proteolytic system regulates transformation.

Carragher NO, Westhoff MA, Riley D, Potter DA, Dutt P, Elce JS, Greer PA, Frame MC. Carragher NO, et al. Mol Cell Biol. 2002 Jan;22(1):257-69. doi: 10.1128/MCB.22.1.257-269.2002. Mol Cell Biol. 2002. PMID: 11739739 Free PMC article.

5

v-Src's hold over actin and cell adhesions.

Frame MC, Fincham VJ, Carragher NO, Wyke JA. Frame MC, et al. Among authors: carragher no. Nat Rev Mol Cell Biol. 2002 Apr;3(4):233-45. doi: 10.1038/nrm779. Nat Rev Mol Cell Biol. 2002. PMID: 11994743 Review.

6

Calpain: a role in cell transformation and migration.

Carragher NO, Frame MC. Carragher NO, et al. Int J Biochem Cell Biol. 2002 Dec;34(12):1539-43. doi: 10.1016/s1357-2725(02)00069-9. Int J Biochem Cell Biol. 2002. PMID: 12379276 Review.

7

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.

Carragher NO, Westhoff MA, Fincham VJ, Schaller MD, Frame MC. Carragher NO, et al. Curr Biol. 2003 Aug 19;13(16):1442-50. doi: 10.1016/s0960-9822(03)00544-x. Curr Biol. 2003. PMID: 12932330 Free article.

8

Calpain activity is generally elevated during transformation but has oncogene-specific biological functions.

Carragher NO, Fonseca BD, Frame MC. Carragher NO, et al. Neoplasia. 2004 Jan-Feb;6(1):53-73. doi: 10.1016/s1476-5586(04)80053-8. Neoplasia. 2004. PMID: 15068671 Free PMC article.

9

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion.

Carragher NO, Frame MC. Carragher NO, et al. Trends Cell Biol. 2004 May;14(5):241-9. doi: 10.1016/j.tcb.2004.03.011. Trends Cell Biol. 2004. PMID: 15130580 Review.

10

SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling.

Westhoff MA, Serrels B, Fincham VJ, Frame MC, Carragher NO. Westhoff MA, et al. Among authors: carragher no. Mol Cell Biol. 2004 Sep;24(18):8113-33. doi: 10.1128/MCB.24.18.8113-8133.2004. Mol Cell Biol. 2004. PMID: 15340073 Free PMC article.

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