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Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol.
Yim H, Haselbeck R, Niu W, Pujol-Baxley C, Burgard A, Boldt J, Khandurina J, Trawick JD, Osterhout RE, Stephen R, Estadilla J, Teisan S, Schreyer HB, Andrae S, Yang TH, Lee SY, Burk MJ, Van Dien S. Yim H, et al. Among authors: osterhout re. Nat Chem Biol. 2011 May 22;7(7):445-52. doi: 10.1038/nchembio.580. Nat Chem Biol. 2011. PMID: 21602812
An integrated biotechnology platform for developing sustainable chemical processes.
Barton NR, Burgard AP, Burk MJ, Crater JS, Osterhout RE, Pharkya P, Steer BA, Sun J, Trawick JD, Van Dien SJ, Yang TH, Yim H. Barton NR, et al. Among authors: osterhout re. J Ind Microbiol Biotechnol. 2015 Mar;42(3):349-60. doi: 10.1007/s10295-014-1541-1. Epub 2014 Nov 22. J Ind Microbiol Biotechnol. 2015. PMID: 25416472 Review.
Seralutinib in adults with pulmonary arterial hypertension (TORREY): a randomised, double-blind, placebo-controlled phase 2 trial.
Frantz RP, McLaughlin VV, Sahay S, Escribano Subías P, Zolty RL, Benza RL, Channick RN, Chin KM, Hemnes AR, Howard LS, Sitbon O, Vachiéry JL, Zamanian RT, Cravets M, Roscigno RF, Mottola D, Osterhout R, Bruey JM, Elman E, Tompkins CA, Parsley E, Aranda R, Zisman LS, Ghofrani HA; TORREY Study Investigators. Frantz RP, et al. Among authors: osterhout r. Lancet Respir Med. 2024 May 2:S2213-2600(24)00072-9. doi: 10.1016/S2213-2600(24)00072-9. Online ahead of print. Lancet Respir Med. 2024. PMID: 38705167
Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity.
Liu X, Hogg GD, Zuo C, Borcherding NC, Baer JM, Lander VE, Kang LI, Knolhoff BL, Ahmad F, Osterhout RE, Galkin AV, Bruey JM, Carter LL, Mpoy C, Vij KR, Fields RC, Schwarz JK, Park H, Gupta V, DeNardo DG. Liu X, et al. Among authors: osterhout re. Cancer Cell. 2023 Jun 12;41(6):1073-1090.e12. doi: 10.1016/j.ccell.2023.04.018. Epub 2023 May 25. Cancer Cell. 2023. PMID: 37236195 Free PMC article.
Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension.
Galkin A, Sitapara R, Clemons B, Garcia E, Kennedy M, Guimond D, Carter LL, Douthitt A, Osterhout R, Gandjeva A, Slee D, Salter-Cid L, Tuder RM, Zisman LS. Galkin A, et al. Among authors: osterhout r. Eur Respir J. 2022 Dec 1;60(6):2102356. doi: 10.1183/13993003.02356-2021. Print 2022 Dec. Eur Respir J. 2022. PMID: 35680144 Free PMC article.
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