Hilbert BJ - Search Results

1

Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP).

Korwar S, Morris BL, Parikh HI, Coover RA, Doughty TW, Love IM, Hilbert BJ, Royer WE Jr, Kellogg GE, Grossman SR, Ellis KC. Korwar S, et al. Among authors: hilbert bj. Bioorg Med Chem. 2016 Jun 15;24(12):2707-15. doi: 10.1016/j.bmc.2016.04.037. Epub 2016 Apr 20. Bioorg Med Chem. 2016. PMID: 27156192 Free PMC article.

2

Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.

Hilbert BJ, Grossman SR, Schiffer CA, Royer WE Jr. Hilbert BJ, et al. FEBS Lett. 2014 May 2;588(9):1743-8. doi: 10.1016/j.febslet.2014.03.026. Epub 2014 Mar 19. FEBS Lett. 2014. PMID: 24657618 Free PMC article.

3

Structure-guided design of a high affinity inhibitor to human CtBP.

Hilbert BJ, Morris BL, Ellis KC, Paulsen JL, Schiffer CA, Grossman SR, Royer WE Jr. Hilbert BJ, et al. ACS Chem Biol. 2015 Apr 17;10(4):1118-27. doi: 10.1021/cb500820b. Epub 2015 Jan 30. ACS Chem Biol. 2015. PMID: 25636004 Free PMC article.

4

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.

Kouno T, Silvas TV, Hilbert BJ, Shandilya SMD, Bohn MF, Kelch BA, Royer WE, Somasundaran M, Kurt Yilmaz N, Matsuo H, Schiffer CA. Kouno T, et al. Among authors: hilbert bj. Nat Commun. 2017 Apr 28;8:15024. doi: 10.1038/ncomms15024. Nat Commun. 2017. PMID: 28452355 Free PMC article.

5

A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.

Duffy CM, Hilbert BJ, Kelch BA. Duffy CM, et al. Among authors: hilbert bj. J Mol Biol. 2016 Mar 27;428(6):1023-1040. doi: 10.1016/j.jmb.2015.11.029. Epub 2015 Dec 11. J Mol Biol. 2016. PMID: 26688547

6

A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry.

Hayes JA, Hilbert BJ, Gaubitz C, Stone NP, Kelch BA. Hayes JA, et al. Among authors: hilbert bj. J Biol Chem. 2020 Mar 20;295(12):3783-3793. doi: 10.1074/jbc.RA119.012224. Epub 2020 Feb 3. J Biol Chem. 2020. PMID: 32014998 Free PMC article.

7

The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain.

Hilbert BJ, Hayes JA, Stone NP, Xu RG, Kelch BA. Hilbert BJ, et al. Nucleic Acids Res. 2017 Apr 7;45(6):3591-3605. doi: 10.1093/nar/gkw1356. Nucleic Acids Res. 2017. PMID: 28082398 Free PMC article.

8

A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein.

Stone NP, Hilbert BJ, Hidalgo D, Halloran KT, Lee J, Sontheimer EJ, Kelch BA. Stone NP, et al. Among authors: hilbert bj. Structure. 2018 Jul 3;26(7):936-947.e3. doi: 10.1016/j.str.2018.04.008. Epub 2018 May 17. Structure. 2018. PMID: 29779790 Free PMC article.

9

Structure and mechanism of the ATPase that powers viral genome packaging.

Hilbert BJ, Hayes JA, Stone NP, Duffy CM, Sankaran B, Kelch BA. Hilbert BJ, et al. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3792-9. doi: 10.1073/pnas.1506951112. Epub 2015 Jul 6. Proc Natl Acad Sci U S A. 2015. PMID: 26150523 Free PMC article.

10

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.

Avnir Y, Prachanronarong KL, Zhang Z, Hou S, Peterson EC, Sui J, Zayed H, Kurella VB, McGuire AT, Stamatatos L, Hilbert BJ, Bohn MF, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Goodall M, Jefferis R, Zhu Q, Kurt Yilmaz N, Schiffer CA, Marasco WA. Avnir Y, et al. Among authors: hilbert bj. Cell Rep. 2017 Dec 12;21(11):3243-3255. doi: 10.1016/j.celrep.2017.11.056. Cell Rep. 2017. PMID: 29241550 Free PMC article.

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