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Increase in P-glycoprotein levels in the blood-brain barrier of partial portal vein ligation /chronic hyperammonemia rats is medicated by ammonia/reactive oxygen species/ERK1/2 activation: In vitro and in vivo studies.
Zhou Y, Zhou J, Li P, Xie Q, Sun B, Li Y, Chen Y, Zhao K, Yang T, Zhu L, Xu J, Liu X, Liu L. Zhou Y, et al. Among authors: chen y. Eur J Pharmacol. 2019 Mar 5;846:119-127. doi: 10.1016/j.ejphar.2019.01.005. Epub 2019 Jan 9. Eur J Pharmacol. 2019. PMID: 30639310
Simultaneously predict pharmacokinetic interaction of rifampicin with oral versus intravenous substrates of cytochrome P450 3A/P‑glycoprotein to healthy human using a semi-physiologically based pharmacokinetic model involving both enzyme and transporter turnover.
Qian CQ, Zhao KJ, Chen Y, Liu L, Liu XD. Qian CQ, et al. Among authors: chen y. Eur J Pharm Sci. 2019 Jun 15;134:194-204. doi: 10.1016/j.ejps.2019.04.026. Epub 2019 Apr 29. Eur J Pharm Sci. 2019. PMID: 31047967
Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters.
Wang Z, Yang H, Xu J, Zhao K, Chen Y, Liang L, Li P, Chen N, Geng D, Zhang X, Liu X, Liu L. Wang Z, et al. Among authors: chen n, chen y. Drug Metab Dispos. 2019 Oct;47(10):1066-1079. doi: 10.1124/dmd.118.085902. Epub 2019 Aug 9. Drug Metab Dispos. 2019. PMID: 31399507
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