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FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity.
Wiesner J, Ziemann C, Hintz M, Reichenberg A, Ortmann R, Schlitzer M, Fuhst R, Timmesfeld N, Vilcinskas A, Jomaa H. Wiesner J, et al. Among authors: schlitzer m. Virulence. 2016 Aug 17;7(6):718-28. doi: 10.1080/21505594.2016.1195537. Epub 2016 Jun 3. Virulence. 2016. PMID: 27260413 Free PMC article.
Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity.
Reichenberg A, Wiesner J, Weidemeyer C, Dreiseidler E, Sanderbrand S, Altincicek B, Beck E, Schlitzer M, Jomaa H. Reichenberg A, et al. Among authors: schlitzer m. Bioorg Med Chem Lett. 2001 Mar 26;11(6):833-5. doi: 10.1016/s0960-894x(01)00075-0. Bioorg Med Chem Lett. 2001. PMID: 11277531
Discovery of a novel lead structure for anti-malarials.
Wiesner J, Wissner P, Dahse HM, Jomaa H, Schlitzer M. Wiesner J, et al. Among authors: schlitzer m. Bioorg Med Chem. 2001 Mar;9(3):785-92. doi: 10.1016/s0968-0896(00)00296-0. Bioorg Med Chem. 2001. PMID: 11310613
94 results