Vargiu AV - Search Results

1

Editorial: Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria.

Vargiu AV, Pos KM, Poole K, Nikaido H. Vargiu AV, et al. Front Microbiol. 2016 May 31;7:833. doi: 10.3389/fmicb.2016.00833. eCollection 2016. Front Microbiol. 2016. PMID: 27303401 Free PMC article. No abstract available.

2

Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations.

Vargiu AV, Collu F, Schulz R, Pos KM, Zacharias M, Kleinekathöfer U, Ruggerone P. Vargiu AV, et al. J Am Chem Soc. 2011 Jul 20;133(28):10704-7. doi: 10.1021/ja202666x. Epub 2011 Jun 27. J Am Chem Soc. 2011. PMID: 21707050

3

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations.

Vargiu AV, Nikaido H. Vargiu AV, et al. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20637-42. doi: 10.1073/pnas.1218348109. Epub 2012 Nov 21. Proc Natl Acad Sci U S A. 2012. PMID: 23175790 Free PMC article.

4

RND efflux pumps: structural information translated into function and inhibition mechanisms.

Ruggerone P, Murakami S, Pos KM, Vargiu AV. Ruggerone P, et al. Among authors: vargiu av. Curr Top Med Chem. 2013;13(24):3079-100. doi: 10.2174/15680266113136660220. Curr Top Med Chem. 2013. PMID: 24200360 Review.

5

Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB.

Kinana AD, Vargiu AV, Nikaido H. Kinana AD, et al. Among authors: vargiu av. Biochemistry. 2013 Nov 19;52(46):8342-51. doi: 10.1021/bi401303v. Epub 2013 Nov 11. Biochemistry. 2013. PMID: 24205856 Free PMC article.

6

Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors.

Vargiu AV, Ruggerone P, Opperman TJ, Nguyen ST, Nikaido H. Vargiu AV, et al. Antimicrob Agents Chemother. 2014 Oct;58(10):6224-34. doi: 10.1128/AAC.03283-14. Epub 2014 Aug 11. Antimicrob Agents Chemother. 2014. PMID: 25114133 Free PMC article.

7

Aminoacyl β-naphthylamides as substrates and modulators of AcrB multidrug efflux pump.

Kinana AD, Vargiu AV, May T, Nikaido H. Kinana AD, et al. Among authors: vargiu av. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1405-10. doi: 10.1073/pnas.1525143113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787896 Free PMC article.

8

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.

Sjuts H, Vargiu AV, Kwasny SM, Nguyen ST, Kim HS, Ding X, Ornik AR, Ruggerone P, Bowlin TL, Nikaido H, Pos KM, Opperman TJ. Sjuts H, et al. Among authors: vargiu av. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3509-14. doi: 10.1073/pnas.1602472113. Epub 2016 Mar 14. Proc Natl Acad Sci U S A. 2016. PMID: 26976576 Free PMC article.

9

Effect of site-directed mutations in multidrug efflux pump AcrB examined by quantitative efflux assays.

Kinana AD, Vargiu AV, Nikaido H. Kinana AD, et al. Among authors: vargiu av. Biochem Biophys Res Commun. 2016 Nov 25;480(4):552-557. doi: 10.1016/j.bbrc.2016.10.083. Epub 2016 Oct 24. Biochem Biophys Res Commun. 2016. PMID: 27789287 Free PMC article.

10

A New Critical Conformational Determinant of Multidrug Efflux by an MFS Transporter.

Zomot E, Yardeni EH, Vargiu AV, Tam HK, Malloci G, Ramaswamy VK, Perach M, Ruggerone P, Pos KM, Bibi E. Zomot E, et al. Among authors: vargiu av. J Mol Biol. 2018 Apr 27;430(9):1368-1385. doi: 10.1016/j.jmb.2018.02.026. Epub 2018 Mar 9. J Mol Biol. 2018. PMID: 29530612 Free article.

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