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A CRISPR screen defines a signal peptide processing pathway required by flaviviruses.
Zhang R, Miner JJ, Gorman MJ, Rausch K, Ramage H, White JP, Zuiani A, Zhang P, Fernandez E, Zhang Q, Dowd KA, Pierson TC, Cherry S, Diamond MS. Zhang R, et al. Among authors: ramage h. Nature. 2016 Jul 7;535(7610):164-8. doi: 10.1038/nature18625. Epub 2016 Jun 17. Nature. 2016. PMID: 27383988 Free PMC article.
Envelope protein ubiquitination drives entry and pathogenesis of Zika virus.
Giraldo MI, Xia H, Aguilera-Aguirre L, Hage A, van Tol S, Shan C, Xie X, Sturdevant GL, Robertson SJ, McNally KL, Meade-White K, Azar SR, Rossi SL, Maury W, Woodson M, Ramage H, Johnson JR, Krogan NJ, Morais MC, Best SM, Shi PY, Rajsbaum R. Giraldo MI, et al. Among authors: ramage h. Nature. 2020 Sep;585(7825):414-419. doi: 10.1038/s41586-020-2457-8. Epub 2020 Jul 8. Nature. 2020. PMID: 32641828 Free PMC article.
Pharmacological activation of STING blocks SARS-CoV-2 infection.
Li M, Ferretti M, Ying B, Descamps H, Lee E, Dittmar M, Lee JS, Whig K, Kamalia B, Dohnalová L, Uhr G, Zarkoob H, Chen YC, Ramage H, Ferrer M, Lynch K, Schultz DC, Thaiss CA, Diamond MS, Cherry S. Li M, et al. Among authors: ramage h. Sci Immunol. 2021 May 18;6(59):eabi9007. doi: 10.1126/sciimmunol.abi9007. Sci Immunol. 2021. PMID: 34010142 Free PMC article.
Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.
Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ. Shah PS, et al. Cell. 2018 Dec 13;175(7):1931-1945.e18. doi: 10.1016/j.cell.2018.11.028. Cell. 2018. PMID: 30550790 Free PMC article.
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2.
Dittmar M, Lee JS, Whig K, Segrist E, Li M, Kamalia B, Castellana L, Ayyanathan K, Cardenas-Diaz FL, Morrisey EE, Truitt R, Yang W, Jurado K, Samby K, Ramage H, Schultz DC, Cherry S. Dittmar M, et al. Among authors: ramage h. Cell Rep. 2021 Apr 6;35(1):108959. doi: 10.1016/j.celrep.2021.108959. Epub 2021 Mar 23. Cell Rep. 2021. PMID: 33811811 Free PMC article.
Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition.
Liu X, Verma A, Garcia G, Ramage H, Myers RL, Lucas A, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. Liu X, et al. Among authors: ramage h. medRxiv [Preprint]. 2021 Jul 21:2021.02.17.21251933. doi: 10.1101/2021.02.17.21251933. medRxiv. 2021. Update in: Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2113401118. doi: 10.1073/pnas.2113401118. PMID: 33655282 Free PMC article. Updated. Preprint.
31 results