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Page 1
Trypsin inhibitors for the treatment of pancreatitis.
Brandl T, Simic O, Skaanderup PR, Namoto K, Berst F, Ehrhardt C, Schiering N, Mueller I, Woelcke J. Brandl T, et al. Among authors: namoto k. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4340-4. doi: 10.1016/j.bmcl.2016.07.029. Epub 2016 Jul 17. Bioorg Med Chem Lett. 2016. PMID: 27476144
Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
Lorthiois E, Roache J, Barnes-Seeman D, Altmann E, Hassiepen U, Turner G, Duvadie R, Hornak V, Karki RG, Schiering N, Weihofen WA, Perruccio F, Calhoun A, Fazal T, Dedic D, Durand C, Dussauge S, Fettis K, Tritsch F, Dentel C, Druet A, Liu D, Kirman L, Lachal J, Namoto K, Bevan D, Mo R, Monnet G, Muller L, Zessis R, Huang X, Lindsley L, Currie T, Chiu YH, Fridrich C, Delgado P, Wang S, Hollis-Symynkywicz M, Berghausen J, Williams E, Liu H, Liang G, Kim H, Hoffmann P, Hein A, Ramage P, D'Arcy A, Harlfinger S, Renatus M, Ruedisser S, Feldman D, Elliott J, Sedrani R, Maibaum J, Adams CM. Lorthiois E, et al. Among authors: namoto k. J Med Chem. 2020 Aug 13;63(15):8088-8113. doi: 10.1021/acs.jmedchem.0c00279. Epub 2020 Jul 21. J Med Chem. 2020. PMID: 32551603
Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes.
Sutton JM, Clark DE, Dunsdon SJ, Fenton G, Fillmore A, Harris NV, Higgs C, Hurley CA, Krintel SL, MacKenzie RE, Duttaroy A, Gangl E, Maniara W, Sedrani R, Namoto K, Ostermann N, Gerhartz B, Sirockin F, Trappe J, Hassiepen U, Baeschlin DK. Sutton JM, et al. Among authors: namoto k. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1464-8. doi: 10.1016/j.bmcl.2011.11.054. Epub 2011 Nov 20. Bioorg Med Chem Lett. 2012. PMID: 22177783
In-cell selectivity profiling of serine protease inhibitors by activity-based proteomics.
Gillet LC, Namoto K, Ruchti A, Hoving S, Boesch D, Inverardi B, Mueller D, Coulot M, Schindler P, Schweigler P, Bernardi A, Gil-Parrado S. Gillet LC, et al. Among authors: namoto k. Mol Cell Proteomics. 2008 Jul;7(7):1241-53. doi: 10.1074/mcp.M700505-MCP200. Epub 2008 Mar 24. Mol Cell Proteomics. 2008. PMID: 18364346 Free article.
DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect.
Kim M, Minoux M, Piaia A, Kueng B, Gapp B, Weber D, Haller C, Barbieri S, Namoto K, Lorenz T, Wirsching J, Bassilana F, Dietrich W, Rijli FM, Ksiazek I. Kim M, et al. Among authors: namoto k. Dev Biol. 2017 Nov 15;431(2):297-308. doi: 10.1016/j.ydbio.2017.09.001. Epub 2017 Sep 6. Dev Biol. 2017. PMID: 28887018 Free article.
Chemical and biological investigations of beta-oligoarginines.
Seebach D, Namoto K, Mahajan YR, Bindschädler P, Sustmann R, Kirsch M, Ryder NS, Weiss M, Sauer M, Roth C, Werner S, Beer HD, Munding C, Walde P, Voser M. Seebach D, et al. Among authors: namoto k. Chem Biodivers. 2004 Jan;1(1):65-97. doi: 10.1002/cbdv.200490014. Chem Biodivers. 2004. PMID: 17191776
20 results