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ALDH2 mediates 5-nitrofuran activity in multiple species.
Zhou L, Ishizaki H, Spitzer M, Taylor KL, Temperley ND, Johnson SL, Brear P, Gautier P, Zeng Z, Mitchell A, Narayan V, McNeil EM, Melton DW, Smith TK, Tyers M, Westwood NJ, Patton EE. Zhou L, et al. Among authors: brear p. Chem Biol. 2012 Jul 27;19(7):883-92. doi: 10.1016/j.chembiol.2012.05.017. Chem Biol. 2012. PMID: 22840776 Free PMC article.
Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α.
Brear P, Ball D, Stott K, D'Arcy S, Hyvönen M. Brear P, et al. J Med Chem. 2020 Nov 12;63(21):12786-12798. doi: 10.1021/acs.jmedchem.0c01173. Epub 2020 Oct 29. J Med Chem. 2020. PMID: 33119282 Free PMC article.
ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species.
Zhou L, Ishizaki H, Spitzer M, Taylor KL, Temperley ND, Johnson SL, Brear P, Gautier P, Zeng Z, Mitchell A, Narayan V, McNeil EM, Melton DW, Smith TK, Tyers M, Westwood NJ, Patton EE. Zhou L, et al. Among authors: brear p. Cell Chem Biol. 2020 Nov 19;27(11):1452. doi: 10.1016/j.chembiol.2020.10.011. Cell Chem Biol. 2020. PMID: 33217312 Free PMC article. No abstract available.
Novel non-ATP competitive small molecules targeting the CK2 α/β interface.
Brear P, North A, Iegre J, Hadje Georgiou K, Lubin A, Carro L, Green W, Sore HF, Hyvönen M, Spring DR. Brear P, et al. Bioorg Med Chem. 2018 Jul 15;26(11):3016-3020. doi: 10.1016/j.bmc.2018.05.011. Epub 2018 May 9. Bioorg Med Chem. 2018. PMID: 29759799 Free PMC article.
37 results