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UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S. Andrews ZB, et al. Among authors: shulman gi. Nature. 2008 Aug 14;454(7206):846-51. doi: 10.1038/nature07181. Epub 2008 Jul 30. Nature. 2008. PMID: 18668043 Free PMC article.
The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.
Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, Dong J, Zhang D, Jurczak MJ, Löffler MG, Cresswell J, Yu XX, Murray SF, Bhanot S, Monia BP, Bogan JS, Samuel V, Shulman GI. Nagai Y, et al. Among authors: shulman gi. Cell Metab. 2009 Mar;9(3):252-64. doi: 10.1016/j.cmet.2009.01.011. Cell Metab. 2009. PMID: 19254570 Free PMC article.
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
Erion DM, Yonemitsu S, Nie Y, Nagai Y, Gillum MP, Hsiao JJ, Iwasaki T, Stark R, Weismann D, Yu XX, Murray SF, Bhanot S, Monia BP, Horvath TL, Gao Q, Samuel VT, Shulman GI. Erion DM, et al. Among authors: shulman gi. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11288-93. doi: 10.1073/pnas.0812931106. Epub 2009 Jun 22. Proc Natl Acad Sci U S A. 2009. PMID: 19549853 Free PMC article.
Uncoupling protein-2 decreases the lipogenic actions of ghrelin.
Andrews ZB, Erion DM, Beiler R, Choi CS, Shulman GI, Horvath TL. Andrews ZB, et al. Among authors: shulman gi. Endocrinology. 2010 May;151(5):2078-86. doi: 10.1210/en.2009-0850. Epub 2010 Feb 26. Endocrinology. 2010. PMID: 20189996 Free PMC article.
A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain.
Jornayvaz FR, Jurczak MJ, Lee HY, Birkenfeld AL, Frederick DW, Zhang D, Zhang XM, Samuel VT, Shulman GI. Jornayvaz FR, et al. Among authors: shulman gi. Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E808-15. doi: 10.1152/ajpendo.00361.2010. Epub 2010 Aug 31. Am J Physiol Endocrinol Metab. 2010. PMID: 20807839 Free PMC article.
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.
Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, Rabinovitch PS, Santos JH, Petersen KF, Samuel VT, Shulman GI. Lee HY, et al. Among authors: shulman gi. Cell Metab. 2010 Dec 1;12(6):668-74. doi: 10.1016/j.cmet.2010.11.004. Cell Metab. 2010. PMID: 21109199 Free PMC article.
589 results