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Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Tice CM, Noto PB, Fan KY, Zhao W, Lotesta SD, Dong C, Marcus AP, Zheng YJ, Chen G, Wu Z, Van Orden R, Zhou J, Bukhtiyarov Y, Zhao Y, Lipinski K, Howard L, Guo J, Kandpal G, Meng S, Hardy A, Krosky P, Gregg RE, Leftheris K, McKeever BM, Singh SB, Lala D, McGeehan GM, Zhuang L, Claremon DA. Tice CM, et al. Among authors: hardy a. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5044-5050. doi: 10.1016/j.bmcl.2016.08.089. Epub 2016 Aug 29. Bioorg Med Chem Lett. 2016. PMID: 27599745
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.
Zheng Y, Zhuang L, Fan KY, Tice CM, Zhao W, Dong C, Lotesta SD, Leftheris K, Lindblom PR, Liu Z, Shimada J, Noto PB, Meng S, Hardy A, Howard L, Krosky P, Guo J, Lipinski K, Kandpal G, Bukhtiyarov Y, Zhao Y, Lala D, Van Orden R, Zhou J, Chen G, Wu Z, McKeever BM, McGeehan GM, Gregg RE, Claremon DA, Singh SB. Zheng Y, et al. Among authors: hardy a. J Med Chem. 2016 Apr 14;59(7):3264-71. doi: 10.1021/acs.jmedchem.5b02029. Epub 2016 Mar 29. J Med Chem. 2016. PMID: 26990539
Association of Patient-Surgeon and Patient-Physical Therapist Relationships With Return to Sports After ACL Reconstruction: The Untested Dimension in Outcome Assessments.
Moussa MK, Lefèvre N, Valentin E, Khalaf Z, Meyer A, Grimaud O, Bohu Y, Gerometta A, Khiami F, Hardy A. Moussa MK, et al. Among authors: hardy a. Orthop J Sports Med. 2024 Jun 12;12(6):23259671241254749. doi: 10.1177/23259671241254749. eCollection 2024 Jun. Orthop J Sports Med. 2024. PMID: 38881855 Free PMC article.
Male sex, revision surgery, low volume of anterior cruciate ligament remnant, and significant instability are risk factors for Posterior Root Tear of the Lateral Meniscus in patients undergoing Anterior Cruciate Ligament Reconstruction.
Lambrey PJ, Fayard JM, Graveleau N, Toanen C, Noailles T, Letartre R, Barth J, Cavaignac E; Francophone society of Arthroscopy ACL registry study group,; Bouguennec N, Thaunat M. Lambrey PJ, et al. Arthroscopy. 2024 Jun 12:S0749-8063(24)00410-9. doi: 10.1016/j.arthro.2024.05.028. Online ahead of print. Arthroscopy. 2024. PMID: 38876444
Bridging the gap from medical to psychological safety assessment: consensus study in a digital mental health context.
Taher R, Bhanushali P, Allan S, Alvarez-Jimenez M, Bolton H, Dennison L, Wallace BE, Hadjistavropoulos HD, Hall CL, Hardy A, Henry AL, Lane S, Maguire T, Moreton A, Moukhtarian TR, Vallejos EP, Shergill S, Stahl D, Thew GR, Timulak L, van den Berg D, Viganò N, Stock BW, Young KS, Yiend J. Taher R, et al. Among authors: hardy a. BJPsych Open. 2024 Jun 3;10(4):e126. doi: 10.1192/bjo.2024.713. BJPsych Open. 2024. PMID: 38828683 Free article.
Digital Mental Health for Schizophrenia and Other Severe Mental Illnesses: An International Consensus on Current Challenges and Potential Solutions.
Smith KA, Hardy A, Vinnikova A, Blease C, Milligan L, Hidalgo-Mazzei D, Lambe S, Marzano L, Uhlhaas PJ, Ostinelli EG, Anmella G, Zangani C, Aronica R, Dwyer B, Torous J, Cipriani A. Smith KA, et al. Among authors: hardy a. JMIR Ment Health. 2024 May 8;11:e57155. doi: 10.2196/57155. JMIR Ment Health. 2024. PMID: 38717799 Free PMC article.
Measurement of Adverse Events in Studies of Digital Health Interventions for Psychosis: Guidance and Recommendations Based on a Literature Search and Framework Analysis of Standard Operating Procedures.
Eisner E, Richardson C, Thomas N, Rus-Calafell M, Syrett S, Firth J, Gumley A, Hardy A, Allan S, Kabir T, Ward T, Priyam A, Bucci S; iCharts network. Eisner E, et al. Among authors: hardy a. Schizophr Bull. 2024 Apr 29:sbae048. doi: 10.1093/schbul/sbae048. Online ahead of print. Schizophr Bull. 2024. PMID: 38683836
870 results