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Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Speranzini V, Rotili D, Ciossani G, Pilotto S, Marrocco B, Forgione M, Lucidi A, Forneris F, Mehdipour P, Velankar S, Mai A, Mattevi A. Speranzini V, et al. Among authors: forneris f. Sci Adv. 2016 Sep 9;2(9):e1601017. doi: 10.1126/sciadv.1601017. eCollection 2016 Sep. Sci Adv. 2016. PMID: 27626075 Free PMC article.
Human histone demethylase LSD1 reads the histone code.
Forneris F, Binda C, Vanoni MA, Battaglioli E, Mattevi A. Forneris F, et al. J Biol Chem. 2005 Dec 16;280(50):41360-5. doi: 10.1074/jbc.M509549200. Epub 2005 Oct 13. J Biol Chem. 2005. PMID: 16223729 Free article.
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