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Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Speranzini V, Rotili D, Ciossani G, Pilotto S, Marrocco B, Forgione M, Lucidi A, Forneris F, Mehdipour P, Velankar S, Mai A, Mattevi A. Speranzini V, et al. Among authors: pilotto s. Sci Adv. 2016 Sep 9;2(9):e1601017. doi: 10.1126/sciadv.1601017. eCollection 2016 Sep. Sci Adv. 2016. PMID: 27626075 Free PMC article.
Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase.
Tortorici M, Borrello MT, Tardugno M, Chiarelli LR, Pilotto S, Ciossani G, Vellore NA, Bailey SG, Cowan J, O'Connell M, Crabb SJ, Packham G, Mai A, Baron R, Ganesan A, Mattevi A. Tortorici M, et al. Among authors: pilotto s. ACS Chem Biol. 2013 Aug 16;8(8):1677-82. doi: 10.1021/cb4001926. Epub 2013 Jun 11. ACS Chem Biol. 2013. PMID: 23721412
Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2.
Toffolo E, Rusconi F, Paganini L, Tortorici M, Pilotto S, Heise C, Verpelli C, Tedeschi G, Maffioli E, Sala C, Mattevi A, Battaglioli E. Toffolo E, et al. Among authors: pilotto s. J Neurochem. 2014 Mar;128(5):603-16. doi: 10.1111/jnc.12457. Epub 2013 Oct 23. J Neurochem. 2014. PMID: 24111946 Free article.
Touch, act and go: landing and operating on nucleosomes.
Speranzini V, Pilotto S, Sixma TK, Mattevi A. Speranzini V, et al. Among authors: pilotto s. EMBO J. 2016 Feb 15;35(4):376-88. doi: 10.15252/embj.201593377. Epub 2016 Jan 19. EMBO J. 2016. PMID: 26787641 Free PMC article. Review.
Structural basis of RNA polymerase inhibition by viral and host factors.
Pilotto S, Fouqueau T, Lukoyanova N, Sheppard C, Lucas-Staat S, Díaz-Santín LM, Matelska D, Prangishvili D, Cheung ACM, Werner F. Pilotto S, et al. Nat Commun. 2021 Sep 17;12(1):5523. doi: 10.1038/s41467-021-25666-5. Nat Commun. 2021. PMID: 34535646 Free PMC article.
204 results