Thompson PE - Search Results

1

Class II Phosphoinositide 3-Kinases as Novel Drug Targets.

Falasca M, Hamilton JR, Selvadurai M, Sundaram K, Adamska A, Thompson PE. Falasca M, et al. Among authors: thompson pe. J Med Chem. 2017 Jan 12;60(1):47-65. doi: 10.1021/acs.jmedchem.6b00963. Epub 2016 Oct 21. J Med Chem. 2017. PMID: 27644332 Review.

2

PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues.

Abbott BM, Thompson PE. Abbott BM, et al. Among authors: thompson pe. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2847-51. doi: 10.1016/j.bmcl.2004.03.043. Bioorg Med Chem Lett. 2004. PMID: 15125945

3

Re-discovering PDE3 inhibitors--new opportunities for a long neglected target.

Thompson PE, Manganiello V, Degerman E. Thompson PE, et al. Curr Top Med Chem. 2007;7(4):421-36. doi: 10.2174/156802607779941224. Curr Top Med Chem. 2007. PMID: 17305583 Review.

4

Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket.

Frazzetto M, Suphioglu C, Zhu J, Schmidt-Kittler O, Jennings IG, Cranmer SL, Jackson SP, Kinzler KW, Vogelstein B, Thompson PE. Frazzetto M, et al. Among authors: thompson pe. Biochem J. 2008 Sep 15;414(3):383-90. doi: 10.1042/BJ20080512. Biochem J. 2008. PMID: 18489260 Free PMC article.

5

Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110α inhibition.

Zheng Z, Amran SI, Thompson PE, Jennings IG. Zheng Z, et al. Among authors: thompson pe. Mol Pharmacol. 2011 Oct;80(4):657-64. doi: 10.1124/mol.111.072546. Epub 2011 Jul 21. Mol Pharmacol. 2011. PMID: 21778304

6

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.

Zheng Z, Amran SI, Zhu J, Schmidt-Kittler O, Kinzler KW, Vogelstein B, Shepherd PR, Thompson PE, Jennings IG. Zheng Z, et al. Among authors: thompson pe. Biochem J. 2012 Jun 15;444(3):529-35. doi: 10.1042/BJ20120499. Biochem J. 2012. PMID: 22502592 Free PMC article.

7

Regioselective synthesis of 5- and 6-methoxybenzimidazole-1,3,5-triazines as inhibitors of phosphoinositide 3-kinase.

Miller MS, Pinson JA, Zheng Z, Jennings IG, Thompson PE. Miller MS, et al. Among authors: thompson pe. Bioorg Med Chem Lett. 2013 Feb 1;23(3):802-5. doi: 10.1016/j.bmcl.2012.11.076. Epub 2012 Dec 1. Bioorg Med Chem Lett. 2013. PMID: 23265896

8

L-Aminoacyl-triazine derivatives are isoform-selective PI3Kβ inhibitors that target non-conserved Asp862 of PI3Kβ.

Pinson JA, Zheng Z, Miller MS, Chalmers DK, Jennings IG, Thompson PE. Pinson JA, et al. Among authors: thompson pe. ACS Med Chem Lett. 2013 Feb 14;4(2):206-210. doi: 10.1021/ml300336j. ACS Med Chem Lett. 2013. PMID: 23795239 Free PMC article.

9

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase.

Mountford SJ, Albiston AL, Charman WN, Ng L, Holien JK, Parker MW, Nicolazzo JA, Thompson PE, Chai SY. Mountford SJ, et al. Among authors: thompson pe. J Med Chem. 2014 Feb 27;57(4):1368-77. doi: 10.1021/jm401540f. Epub 2014 Feb 7. J Med Chem. 2014. PMID: 24471437

10

A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent.

Yap BK, Leung EW, Yagi H, Galea CA, Chhabra S, Chalmers DK, Nicholson SE, Thompson PE, Norton RS. Yap BK, et al. Among authors: thompson pe. J Med Chem. 2014 Aug 28;57(16):7006-15. doi: 10.1021/jm500596j. Epub 2014 Aug 6. J Med Chem. 2014. PMID: 25068993

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