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Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.
J Med Chem. 2016 Oct 13;59(19):9228-9242. doi: 10.1021/acs.jmedchem.6b01169. Epub 2016 Oct 3.
J Med Chem. 2016.
PMID: 27660855
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors.
Patel L, Chandrasekhar J, Evarts J, Haran AC, Ip C, Kaplan JA, Kim M, Koditek D, Lad L, Lepist EI, McGrath ME, Novikov N, Perreault S, Puri KD, Somoza JR, Steiner BH, Stevens KL, Therrien J, Treiberg J, Villaseñor AG, Yeung A, Phillips G.
Patel L, et al. Among authors: haran ac.
J Med Chem. 2016 Apr 14;59(7):3532-48. doi: 10.1021/acs.jmedchem.6b00213. Epub 2016 Mar 29.
J Med Chem. 2016.
PMID: 26980109
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Exogenous PDGF-D is a potent mesangial cell mitogen and causes a severe mesangial proliferative glomerulopathy.
Hudkins KL, Gilbertson DG, Carling M, Taneda S, Hughes SD, Holdren MS, Palmer TE, Topouzis S, Haran AC, Feldhaus AL, Alpers CE.
Hudkins KL, et al. Among authors: haran ac.
J Am Soc Nephrol. 2004 Feb;15(2):286-98. doi: 10.1097/01.asn.0000108522.79652.63.
J Am Soc Nephrol. 2004.
PMID: 14747375
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Additive anti-inflammatory effects of beta 2 adrenoceptor agonists or glucocorticosteroid with roflumilast in human peripheral blood mononuclear cells.
Tannheimer SL, Sorensen EA, Haran AC, Mansfield CN, Wright CD, Salmon M.
Tannheimer SL, et al. Among authors: haran ac.
Pulm Pharmacol Ther. 2012 Apr;25(2):178-84. doi: 10.1016/j.pupt.2012.01.003. Epub 2012 Jan 28.
Pulm Pharmacol Ther. 2012.
PMID: 22306235
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Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma.
Campbell JS, Hughes SD, Gilbertson DG, Palmer TE, Holdren MS, Haran AC, Odell MM, Bauer RL, Ren HP, Haugen HS, Yeh MM, Fausto N.
Campbell JS, et al. Among authors: haran ac.
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3389-94. doi: 10.1073/pnas.0409722102. Epub 2005 Feb 22.
Proc Natl Acad Sci U S A. 2005.
PMID: 15728360
Free PMC article.
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Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation.
Riehle KJ, Johnson MM, Johansson F, Bauer RL, Hayes BJ, Gilbertson DG, Haran AC, Fausto N, Campbell JS.
Riehle KJ, et al. Among authors: haran ac.
Biochim Biophys Acta. 2014 Feb;1842(2):318-25. doi: 10.1016/j.bbadis.2013.11.013. Epub 2013 Nov 19.
Biochim Biophys Acta. 2014.
PMID: 24269585
Free PMC article.
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A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy.
Lei H, Hovland P, Velez G, Haran A, Gilbertson D, Hirose T, Kazlauskas A.
Lei H, et al.
Invest Ophthalmol Vis Sci. 2007 May;48(5):2335-42. doi: 10.1167/iovs.06-0965.
Invest Ophthalmol Vis Sci. 2007.
PMID: 17460299
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