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The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.
Günther C, He GW, Kremer AE, Murphy JM, Petrie EJ, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath MF, Becker C, Wirtz S. Günther C, et al. Among authors: murphy jm. J Clin Invest. 2016 Nov 1;126(11):4346-4360. doi: 10.1172/JCI87545. Epub 2016 Oct 17. J Clin Invest. 2016. PMID: 27756058 Free PMC article.
Evolutionary divergence of the necroptosis effector MLKL.
Tanzer MC, Matti I, Hildebrand JM, Young SN, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM. Tanzer MC, et al. Among authors: murphy jm. Cell Death Differ. 2016 Jul;23(7):1185-97. doi: 10.1038/cdd.2015.169. Epub 2016 Feb 12. Cell Death Differ. 2016. PMID: 26868910 Free PMC article.
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.
Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL. Pearson JS, et al. Among authors: murphy jm. Nat Microbiol. 2017 Jan 13;2:16258. doi: 10.1038/nmicrobiol.2016.258. Nat Microbiol. 2017. PMID: 28085133 Free PMC article.
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.
Petrie EJ, Sandow JJ, Jacobsen AV, Smith BJ, Griffin MDW, Lucet IS, Dai W, Young SN, Tanzer MC, Wardak A, Liang LY, Cowan AD, Hildebrand JM, Kersten WJA, Lessene G, Silke J, Czabotar PE, Webb AI, Murphy JM. Petrie EJ, et al. Among authors: murphy jm. Nat Commun. 2018 Jun 21;9(1):2422. doi: 10.1038/s41467-018-04714-7. Nat Commun. 2018. PMID: 29930286 Free PMC article.
The anticonvulsive Phenhydan® suppresses extrinsic cell death.
Moerke C, Jaco I, Dewitz C, Müller T, Jacobsen AV, Gautheron J, Fritsch J, Schmitz J, Bräsen JH, Günther C, Murphy JM, Kunzendorf U, Meier P, Krautwald S. Moerke C, et al. Among authors: murphy jm. Cell Death Differ. 2019 Sep;26(9):1631-1645. doi: 10.1038/s41418-018-0232-2. Epub 2018 Nov 15. Cell Death Differ. 2019. PMID: 30442947 Free PMC article.
The Structural Basis of Necroptotic Cell Death Signaling.
Petrie EJ, Czabotar PE, Murphy JM. Petrie EJ, et al. Among authors: murphy jm. Trends Biochem Sci. 2019 Jan;44(1):53-63. doi: 10.1016/j.tibs.2018.11.002. Epub 2018 Nov 30. Trends Biochem Sci. 2019. PMID: 30509860 Review.
783 results