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Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.
Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, Zhang Y, Han X, Nakamura T, Masliah E, Yates JR 3rd, Nakanishi N, Andreyev AY, Okamoto S, Jaenisch R, Ambasudhan R, Lipton SA. Ryan SD, et al. Among authors: nakanishi n. Cell. 2013 Dec 5;155(6):1351-64. doi: 10.1016/j.cell.2013.11.009. Epub 2013 Nov 27. Cell. 2013. PMID: 24290359 Free PMC article.
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.
Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA. Talantova M, et al. Among authors: nakanishi n. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2518-27. doi: 10.1073/pnas.1306832110. Epub 2013 Jun 17. Proc Natl Acad Sci U S A. 2013. PMID: 23776240 Free PMC article.
MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress.
Nagar S, Noveral SM, Trudler D, Lopez KM, McKercher SR, Han X, Yates JR 3rd, Piña-Crespo JC, Nakanishi N, Satoh T, Okamoto SI, Lipton SA. Nagar S, et al. Among authors: nakanishi n. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4048-E4056. doi: 10.1073/pnas.1613067114. Epub 2017 May 1. Proc Natl Acad Sci U S A. 2017. PMID: 28461502 Free PMC article.
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo.
Li H, Radford JC, Ragusa MJ, Shea KL, McKercher SR, Zaremba JD, Soussou W, Nie Z, Kang YJ, Nakanishi N, Okamoto S, Roberts AJ, Schwarz JJ, Lipton SA. Li H, et al. Among authors: nakanishi n. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9397-402. doi: 10.1073/pnas.0802876105. Epub 2008 Jul 1. Proc Natl Acad Sci U S A. 2008. PMID: 18599437 Free PMC article.
NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.
Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, Huang X, Sultan A, McKercher SR, Ambasudhan R, Xu H, Wang Y, Geschwind DH, Roberts AJ, Terskikh AV, Rissman RA, Masliah E, Lipton SA, Nakanishi N. Tu S, et al. Among authors: nakanishi n. Nat Commun. 2017 Nov 14;8(1):1488. doi: 10.1038/s41467-017-01563-8. Nat Commun. 2017. PMID: 29133852 Free PMC article.
811 results