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DNA methylation clocks struggle to distinguish inflammaging from healthy aging, but feature rectification improves coherence and enhances detection of inflammaging.
bioRxiv [Preprint]. 2024 Oct 13:2024.10.09.617512. doi: 10.1101/2024.10.09.617512.
bioRxiv. 2024.
PMID: 39416129
Free PMC article.
Preprint.
We further demonstrate that the interplay of disease-related shifts of predictor values and their corresponding weights, which we term feature shifts, contributes to the lack of resolution between health and disease in conventional linear models. ...
We further demonstrate that the interplay of disease-related shifts of predictor values and their corresponding weights, which we term …
Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease.
Mei X, Blanchard J, Luellen C, Conboy MJ, Conboy IM.
Mei X, et al. Among authors: conboy mj.
Aging (Albany NY). 2023 Sep 12;15(17):8552-8575. doi: 10.18632/aging.205046. Epub 2023 Sep 12.
Aging (Albany NY). 2023.
PMID: 37702598
Free PMC article.
We established that dysregulation of such cytosines, measured as the sums of standard deviations of their methylation values, quantifies biological noise, which in our hypothesis is a biomarker of aging and disease. We term this approach a "noise barometer" - the pressure …
We established that dysregulation of such cytosines, measured as the sums of standard deviations of their methylation values, quantifies bio …
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