Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

2 results

Filters applied: . Clear all
Page 1
DNA methylation clocks struggle to distinguish inflammaging from healthy aging, but feature rectification improves coherence and enhances detection of inflammaging.
Skinner CM, Conboy MJ, Conboy IM. Skinner CM, et al. Among authors: conboy mj. bioRxiv [Preprint]. 2024 Oct 13:2024.10.09.617512. doi: 10.1101/2024.10.09.617512. bioRxiv. 2024. PMID: 39416129 Free PMC article. Preprint.
We further demonstrate that the interplay of disease-related shifts of predictor values and their corresponding weights, which we term feature shifts, contributes to the lack of resolution between health and disease in conventional linear models. ...
We further demonstrate that the interplay of disease-related shifts of predictor values and their corresponding weights, which we term
Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease.
Mei X, Blanchard J, Luellen C, Conboy MJ, Conboy IM. Mei X, et al. Among authors: conboy mj. Aging (Albany NY). 2023 Sep 12;15(17):8552-8575. doi: 10.18632/aging.205046. Epub 2023 Sep 12. Aging (Albany NY). 2023. PMID: 37702598 Free PMC article.
We established that dysregulation of such cytosines, measured as the sums of standard deviations of their methylation values, quantifies biological noise, which in our hypothesis is a biomarker of aging and disease. We term this approach a "noise barometer" - the pressure …
We established that dysregulation of such cytosines, measured as the sums of standard deviations of their methylation values, quantifies bio …