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Loss of p300 accelerates MDS-associated leukemogenesis.
Cheng G, Liu F, Asai T, Lai F, Man N, Xu H, Chen S, Greenblatt S, Hamard PJ, Ando K, Chen X, Wang L, Martinez C, Tadi M, Wang L, Xu M, Yang FC, Shiekhattar R, Nimer SD. Cheng G, et al. Among authors: nimer sd. Leukemia. 2017 Jun;31(6):1382-1390. doi: 10.1038/leu.2016.347. Epub 2016 Nov 24. Leukemia. 2017. PMID: 27881875 Free PMC article.
Myelodysplasia: battle in the bone marrow.
Liu Y, Asai T, Nimer SD. Liu Y, et al. Among authors: nimer sd. Nat Med. 2010 Jan;16(1):30-2. doi: 10.1038/nm0110-30. Nat Med. 2010. PMID: 20057420 No abstract available.
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.
Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD. Wang L, et al. Among authors: nimer sd. Science. 2011 Aug 5;333(6043):765-9. doi: 10.1126/science.1201662. Epub 2011 Jul 14. Science. 2011. PMID: 21764752 Free PMC article.
The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.
Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, Sashida G, Zhang Y, Liu Y, Lee J, Menendez S, Yang Y, Yan X, Zhang P, Tenen DG, Osato M, Hsieh JJ, Nimer SD. Huang G, et al. Among authors: nimer sd. Blood. 2011 Dec 15;118(25):6544-52. doi: 10.1182/blood-2010-11-317909. Epub 2011 Oct 19. Blood. 2011. PMID: 22012064 Free PMC article.
280 results