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Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors.
Huang X, Motea EA, Moore ZR, Yao J, Dong Y, Chakrabarti G, Kilgore JA, Silvers MA, Patidar PL, Cholka A, Fattah F, Cha Y, Anderson GG, Kusko R, Peyton M, Yan J, Xie XJ, Sarode V, Williams NS, Minna JD, Beg M, Gerber DE, Bey EA, Boothman DA. Huang X, et al. Among authors: bey ea. Cancer Cell. 2016 Dec 12;30(6):940-952. doi: 10.1016/j.ccell.2016.11.006. Cancer Cell. 2016. PMID: 27960087 Free PMC article.
Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers.
Bey EA, Reinicke KE, Srougi MC, Varnes M, Anderson VE, Pink JJ, Li LS, Patel M, Cao L, Moore Z, Rommel A, Boatman M, Lewis C, Euhus DM, Bornmann WG, Buchsbaum DJ, Spitz DR, Gao J, Boothman DA. Bey EA, et al. Mol Cancer Ther. 2013 Oct;12(10):2110-20. doi: 10.1158/1535-7163.MCT-12-0962. Epub 2013 Jul 24. Mol Cancer Ther. 2013. PMID: 23883585 Free PMC article.
Depleting Tumor-NQO1 Potentiates Anoikis and Inhibits Growth of NSCLC.
Madajewski B, Boatman MA, Chakrabarti G, Boothman DA, Bey EA. Madajewski B, et al. Among authors: bey ea. Mol Cancer Res. 2016 Jan;14(1):14-25. doi: 10.1158/1541-7786.MCR-15-0207-T. Epub 2015 Nov 9. Mol Cancer Res. 2016. PMID: 26553038 Free PMC article.
NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers.
Motea EA, Huang X, Singh N, Kilgore JA, Williams NS, Xie XJ, Gerber DE, Beg MS, Bey EA, Boothman DA. Motea EA, et al. Among authors: bey ea. Clin Cancer Res. 2019 Apr 15;25(8):2601-2609. doi: 10.1158/1078-0432.CCR-18-2560. Epub 2019 Jan 7. Clin Cancer Res. 2019. PMID: 30617135 Free PMC article.
35 results