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Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model.
Waddingham MT, Sonobe T, Tsuchimochi H, Edgley AJ, Sukumaran V, Chen YC, Hansra SS, Schwenke DO, Umetani K, Aoyama K, Yagi N, Kelly DJ, Gaderi S, Herwig M, Kolijn D, Mügge A, Paulus WJ, Ogo T, Shirai M, Hamdani N, Pearson JT. Waddingham MT, et al. J Mol Cell Cardiol. 2019 Dec;137:119-131. doi: 10.1016/j.yjmcc.2019.10.005. Epub 2019 Oct 28. J Mol Cell Cardiol. 2019. PMID: 31669609 Free article.
Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome.
Waddingham MT, Sequeira V, Kuster DWD, Dal Canto E, Handoko ML, de Man FS, da Silva Gonçalves Bós D, Ottenheijm CA, Shen S, van der Pijl RJ, van der Velden J, Paulus WJ, Eringa EC. Waddingham MT, et al. Physiol Rep. 2023 Nov;11(22):e15788. doi: 10.14814/phy2.15788. Physiol Rep. 2023. PMID: 37985159 Free PMC article. Clinical Trial.
Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model.
Pearson JT, Yoshimoto M, Chen YC, Sultani R, Edgley AJ, Nakaoka H, Nishida M, Umetani K, Waddingham MT, Jin HL, Zhang Y, Kelly DJ, Schwenke DO, Inagaki T, Tsuchimochi H, Komuro I, Yamashita S, Shirai M. Pearson JT, et al. Among authors: waddingham mt. Sci Rep. 2017 Dec 22;7(1):18108. doi: 10.1038/s41598-017-18485-6. Sci Rep. 2017. PMID: 29273789 Free PMC article.
Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome.
Surikow SY, Nguyen TH, Stafford I, Chapman M, Chacko S, Singh K, Licari G, Raman B, Kelly DJ, Zhang Y, Waddingham MT, Ngo DT, Bate AP, Chua SJ, Frenneaux MP, Horowitz JD. Surikow SY, et al. Among authors: waddingham mt. JACC Basic Transl Sci. 2018 Apr 18;3(2):213-226. doi: 10.1016/j.jacbts.2017.10.002. eCollection 2018 Apr. JACC Basic Transl Sci. 2018. PMID: 30062207 Free PMC article.
16 results