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Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD.
Yuan T, Yang Y, Chen J, Li W, Li W, Zhang Q, Mi Y, Goswami RS, You JQ, Lin D, Qian MD, Calin S, Liang Y, Miranda RN, Calin GA, Zhou X, Ma L, Zweidler-McKay PA, Liu B, Weng AP, Medeiros LJ, Zhang Y, You MJ. Yuan T, et al. Among authors: you mj, you jq. Leukemia. 2017 Nov;31(11):2355-2364. doi: 10.1038/leu.2017.80. Epub 2017 Mar 10. Leukemia. 2017. PMID: 28280276 Free PMC article.
Long noncoding RNA MALAT1 suppresses breast cancer metastasis.
Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L. Kim J, et al. Among authors: you mj. Nat Genet. 2018 Dec;50(12):1705-1715. doi: 10.1038/s41588-018-0252-3. Epub 2018 Oct 22. Nat Genet. 2018. PMID: 30349115 Free PMC article.
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.
Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B. Liu X, et al. Among authors: you mj. Nat Cell Biol. 2020 Apr;22(4):476-486. doi: 10.1038/s41556-020-0496-x. Epub 2020 Mar 30. Nat Cell Biol. 2020. PMID: 32231310 Free PMC article.
A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis.
Yao F, Deng Y, Zhao Y, Mei Y, Zhang Y, Liu X, Martinez C, Su X, Rosato RR, Teng H, Hang Q, Yap S, Chen D, Wang Y, Chen MM, Zhang M, Liang H, Xie D, Chen X, Zhu H, Chang JC, You MJ, Sun Y, Gan B, Ma L. Yao F, et al. Among authors: you mj. Nat Commun. 2021 Dec 17;12(1):7333. doi: 10.1038/s41467-021-27452-9. Nat Commun. 2021. PMID: 34921145 Free PMC article.
BRCA1-mediated dual regulation of ferroptosis exposes a vulnerability to GPX4 and PARP co-inhibition in BRCA1-deficient cancers.
Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B. Lei G, et al. Among authors: you mj. Cancer Discov. 2024 Mar 28. doi: 10.1158/2159-8290.CD-23-1220. Online ahead of print. Cancer Discov. 2024. PMID: 38552003
188 results