DeGrado WF - Search Results

1

Stapled Voltage-Gated Calcium Channel (Ca_V) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of Ca_V Function.

Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL Jr. Findeisen F, et al. Among authors: degrado wf. ACS Chem Neurosci. 2017 Jun 21;8(6):1313-1326. doi: 10.1021/acschemneuro.6b00454. Epub 2017 Mar 17. ACS Chem Neurosci. 2017. PMID: 28278376 Free PMC article.

2

Selective incorporation of nitrile-based infrared probes into proteins via cysteine alkylation.

Jo H, Culik RM, Korendovych IV, Degrado WF, Gai F. Jo H, et al. Among authors: degrado wf. Biochemistry. 2010 Dec 14;49(49):10354-6. doi: 10.1021/bi101711a. Epub 2010 Nov 17. Biochemistry. 2010. PMID: 21077670 Free PMC article.

3

Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.

Moore DT, Nygren P, Jo H, Boesze-Battaglia K, Bennett JS, DeGrado WF. Moore DT, et al. Among authors: degrado wf. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):793-8. doi: 10.1073/pnas.1117220108. Epub 2011 Dec 30. Proc Natl Acad Sci U S A. 2012. PMID: 22210111 Free PMC article.

4

Using thioamides to site-specifically interrogate the dynamics of hydrogen bond formation in β-sheet folding.

Culik RM, Jo H, DeGrado WF, Gai F. Culik RM, et al. Among authors: degrado wf. J Am Chem Soc. 2012 May 16;134(19):8026-9. doi: 10.1021/ja301681v. Epub 2012 May 2. J Am Chem Soc. 2012. PMID: 22540162 Free PMC article.

5

Development of α-helical calpain probes by mimicking a natural protein-protein interaction.

Jo H, Meinhardt N, Wu Y, Kulkarni S, Hu X, Low KE, Davies PL, DeGrado WF, Greenbaum DC. Jo H, et al. Among authors: degrado wf. J Am Chem Soc. 2012 Oct 24;134(42):17704-13. doi: 10.1021/ja307599z. Epub 2012 Oct 11. J Am Chem Soc. 2012. PMID: 22998171 Free PMC article.

6

Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.

Wang J, Ma C, Wang J, Jo H, Canturk B, Fiorin G, Pinto LH, Lamb RA, Klein ML, DeGrado WF. Wang J, et al. Among authors: degrado wf. J Med Chem. 2013 Apr 11;56(7):2804-12. doi: 10.1021/jm301538e. Epub 2013 Mar 27. J Med Chem. 2013. PMID: 23437766 Free PMC article.

7

Assessment of local friction in protein folding dynamics using a helix cross-linker.

Markiewicz BN, Jo H, Culik RM, DeGrado WF, Gai F. Markiewicz BN, et al. Among authors: degrado wf. J Phys Chem B. 2013 Nov 27;117(47):14688-96. doi: 10.1021/jp409334h. Epub 2013 Nov 18. J Phys Chem B. 2013. PMID: 24205975 Free PMC article.

8

Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.

Wu Y, Canturk B, Jo H, Ma C, Gianti E, Klein ML, Pinto LH, Lamb RA, Fiorin G, Wang J, DeGrado WF. Wu Y, et al. Among authors: degrado wf. J Am Chem Soc. 2014 Dec 31;136(52):17987-95. doi: 10.1021/ja508461m. Epub 2014 Dec 18. J Am Chem Soc. 2014. PMID: 25470189 Free PMC article.

9

Computational design and experimental characterization of peptides intended for pH-dependent membrane insertion and pore formation.

Zhang Y, Bartz R, Grigoryan G, Bryant M, Aaronson J, Beck S, Innocent N, Klein L, Procopio W, Tucker T, Jadhav V, Tellers DM, DeGrado WF. Zhang Y, et al. Among authors: degrado wf. ACS Chem Biol. 2015 Apr 17;10(4):1082-93. doi: 10.1021/cb500759p. Epub 2015 Jan 28. ACS Chem Biol. 2015. PMID: 25630033 Free PMC article.

10

The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.

Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. Reed NI, et al. Among authors: degrado wf. Sci Transl Med. 2015 May 20;7(288):288ra79. doi: 10.1126/scitranslmed.aaa5094. Sci Transl Med. 2015. PMID: 25995225 Free PMC article.

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