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Acute myeloid leukemia stem cell function is preserved in the absence of autophagy.
Porter AH, Leveque-El Mouttie L, Vu T, Bruedigam C, Sutton J, Jacquelin S, Hill GR, MacDonald KPA, Lane SW. Porter AH, et al. Among authors: lane sw. Haematologica. 2017 Sep;102(9):e344-e347. doi: 10.3324/haematol.2017.166389. Epub 2017 May 26. Haematologica. 2017. PMID: 28550181 Free PMC article. No abstract available.
Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera.
Mullally A, Bruedigam C, Poveromo L, Heidel FH, Purdon A, Vu T, Austin R, Heckl D, Breyfogle LJ, Kuhn CP, Kalaitzidis D, Armstrong SA, Williams DA, Hill GR, Ebert BL, Lane SW. Mullally A, et al. Among authors: lane sw. Blood. 2013 May 2;121(18):3692-702. doi: 10.1182/blood-2012-05-432989. Epub 2013 Mar 13. Blood. 2013. PMID: 23487027 Free PMC article.
Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo.
Zhang P, Tey SK, Koyama M, Kuns RD, Olver SD, Lineburg KE, Lor M, Teal BE, Raffelt NC, Raju J, Leveque L, Markey KA, Varelias A, Clouston AD, Lane SW, MacDonald KP, Hill GR. Zhang P, et al. Among authors: lane sw. J Immunol. 2013 Nov 15;191(10):5291-303. doi: 10.4049/jimmunol.1301181. Epub 2013 Oct 11. J Immunol. 2013. PMID: 24123683
Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.
Bruedigam C, Bagger FO, Heidel FH, Paine Kuhn C, Guignes S, Song A, Austin R, Vu T, Lee E, Riyat S, Moore AS, Lock RB, Bullinger L, Hill GR, Armstrong SA, Williams DA, Lane SW. Bruedigam C, et al. Among authors: lane sw. Cell Stem Cell. 2014 Dec 4;15(6):775-90. doi: 10.1016/j.stem.2014.11.010. Cell Stem Cell. 2014. PMID: 25479751 Free PMC article.
Autophagy is required for stem cell mobilization by G-CSF.
Leveque-El Mouttie L, Vu T, Lineburg KE, Kuns RD, Bagger FO, Teal BE, Lor M, Boyle GM, Bruedigam C, Mintern JD, Hill GR, MacDonald KP, Lane SW. Leveque-El Mouttie L, et al. Among authors: lane sw. Blood. 2015 May 7;125(19):2933-6. doi: 10.1182/blood-2014-03-562660. Epub 2015 Mar 18. Blood. 2015. PMID: 25788702 Free article.
Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects.
Gartlan KH, Markey KA, Varelias A, Bunting MD, Koyama M, Kuns RD, Raffelt NC, Olver SD, Lineburg KE, Cheong M, Teal BE, Lor M, Comerford I, Teng MW, Smyth MJ, McCluskey J, Rossjohn J, Stockinger B, Boyle GM, Lane SW, Clouston AD, McColl SR, MacDonald KP, Hill GR. Gartlan KH, et al. Among authors: lane sw. Blood. 2015 Sep 24;126(13):1609-20. doi: 10.1182/blood-2015-01-622662. Epub 2015 Jul 23. Blood. 2015. PMID: 26206951 Free article.
114 results