Laufer S - Search Results

1

Proteasome Activation by Small Molecules.

Leestemaker Y, de Jong A, Witting KF, Penning R, Schuurman K, Rodenko B, Zaal EA, van de Kooij B, Laufer S, Heck AJR, Borst J, Scheper W, Berkers CR, Ovaa H. Leestemaker Y, et al. Among authors: laufer s. Cell Chem Biol. 2017 Jun 22;24(6):725-736.e7. doi: 10.1016/j.chembiol.2017.05.010. Epub 2017 May 25. Cell Chem Biol. 2017. PMID: 28552582 Free article.

2

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.

Koeberle SC, Romir J, Fischer S, Koeberle A, Schattel V, Albrecht W, Grütter C, Werz O, Rauh D, Stehle T, Laufer SA. Koeberle SC, et al. Among authors: laufer sa. Nat Chem Biol. 2011 Dec 25;8(2):141-3. doi: 10.1038/nchembio.761. Nat Chem Biol. 2011. PMID: 22198732

3

Small molecular anti-cytokine agents.

Wagner G, Laufer S. Wagner G, et al. Among authors: laufer s. Med Res Rev. 2006 Jan;26(1):1-62. doi: 10.1002/med.20042. Med Res Rev. 2006. PMID: 16283677 Review.

4

Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis.

Götschel F, Kern C, Lang S, Sparna T, Markmann C, Schwager J, McNelly S, von Weizsäcker F, Laufer S, Hecht A, Merfort I. Götschel F, et al. Among authors: laufer s. Exp Cell Res. 2008 Apr 1;314(6):1351-66. doi: 10.1016/j.yexcr.2007.12.015. Epub 2007 Dec 31. Exp Cell Res. 2008. PMID: 18261723

5

2-Acylaminopyridin-4-ylimidazoles as p38 MAP kinase inhibitors: Design, synthesis, and biological and metabolic evaluations.

Ziegler K, Hauser DR, Unger A, Albrecht W, Laufer SA. Ziegler K, et al. ChemMedChem. 2009 Nov;4(11):1939-48. doi: 10.1002/cmdc.200900242. ChemMedChem. 2009. PMID: 19731280

6

Design, synthesis and SAR of phenylamino-substituted 5,11-dihydro-dibenzo[a,d]cyclohepten-10-ones and 11H-dibenzo[b,f]oxepin-10-ones as p38 MAP kinase inhibitors.

Dorn A, Schattel V, Laufer S. Dorn A, et al. Among authors: laufer s. Bioorg Med Chem Lett. 2010 May 15;20(10):3074-7. doi: 10.1016/j.bmcl.2010.03.107. Epub 2010 Apr 1. Bioorg Med Chem Lett. 2010. PMID: 20418099

7

Optimization of a nonradioactive immunosorbent assay for p38alpha mitogen-activated protein kinase activity.

Goettert M, Graeser R, Laufer SA. Goettert M, et al. Anal Biochem. 2010 Nov 15;406(2):233-4. doi: 10.1016/j.ab.2010.07.007. Epub 2010 Jul 16. Anal Biochem. 2010. PMID: 20638357

8

Tri- and tetrasubstituted imidazoles as p38α mitogen-activated protein kinase inhibitors.

Laufer S, Hauser D, Stegmiller T, Bracht C, Ruff K, Schattel V, Albrecht W, Koch P. Laufer S, et al. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6671-5. doi: 10.1016/j.bmcl.2010.09.012. Epub 2010 Sep 9. Bioorg Med Chem Lett. 2010. PMID: 20934337

9

Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids.

Goettert M, Schattel V, Koch P, Merfort I, Laufer S. Goettert M, et al. Among authors: laufer s. Chembiochem. 2010 Dec 10;11(18):2579-88. doi: 10.1002/cbic.201000487. Chembiochem. 2010. PMID: 21108268

10

A direct ELISA assay for quantitative determination of the inhibitory potency of small molecules inhibitors for JNK3.

Goettert M, Luik S, Graeser R, Laufer SA. Goettert M, et al. Among authors: laufer sa. J Pharm Biomed Anal. 2011 Apr 28;55(1):236-40. doi: 10.1016/j.jpba.2011.01.014. Epub 2011 Jan 22. J Pharm Biomed Anal. 2011. PMID: 21316174

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