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Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth.
Oncogenesis. 2017 Jun 12;6(6):e346. doi: 10.1038/oncsis.2017.42.
Oncogenesis. 2017.
PMID: 28604763
Free PMC article.
PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin.
Kershaw RM, Siddiqui YH, Roberts D, Jayaraman PS, Gaston K.
Kershaw RM, et al.
Oncogene. 2014 Dec 4;33(49):5592-600. doi: 10.1038/onc.2013.496. Epub 2013 Nov 18.
Oncogene. 2014.
PMID: 24240683
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CK2 abrogates the inhibitory effects of PRH/HHEX on prostate cancer cell migration and invasion and acts through PRH to control cell proliferation.
Siddiqui YH, Kershaw RM, Humphreys EH, Assis Junior EM, Chaudhri S, Jayaraman PS, Gaston K.
Siddiqui YH, et al. Among authors: kershaw rm.
Oncogenesis. 2017 Jan 30;6(1):e293. doi: 10.1038/oncsis.2016.82.
Oncogenesis. 2017.
PMID: 28134934
Free PMC article.
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Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression.
Stepanova V, Jayaraman PS, Zaitsev SV, Lebedeva T, Bdeir K, Kershaw R, Holman KR, Parfyonova YV, Semina EV, Beloglazova IB, Tkachuk VA, Cines DB.
Stepanova V, et al.
J Biol Chem. 2016 Jul 15;291(29):15029-45. doi: 10.1074/jbc.M115.678490. Epub 2016 May 4.
J Biol Chem. 2016.
PMID: 27151212
Free PMC article.
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Repair of oxidative DNA damage is delayed in the Ser326Cys polymorphic variant of the base excision repair protein OGG1.
Kershaw RM, Hodges NJ.
Kershaw RM, et al.
Mutagenesis. 2012 Jul;27(4):501-10. doi: 10.1093/mutage/ges012. Epub 2012 Mar 25.
Mutagenesis. 2012.
PMID: 22451681
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Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells.
Mirbahai L, Kershaw RM, Green RM, Hayden RE, Meldrum RA, Hodges NJ.
Mirbahai L, et al. Among authors: kershaw rm.
DNA Repair (Amst). 2010 Feb 4;9(2):144-52. doi: 10.1016/j.dnarep.2009.11.009. Epub 2009 Dec 29.
DNA Repair (Amst). 2010.
PMID: 20042377
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Cellular accumulation of Cys326-OGG1 protein complexes under conditions of oxidative stress.
Kaur MP, Guggenheim EJ, Pulisciano C, Akbar S, Kershaw RM, Hodges NJ.
Kaur MP, et al. Among authors: kershaw rm.
Biochem Biophys Res Commun. 2014 Apr 25;447(1):12-8. doi: 10.1016/j.bbrc.2014.03.044. Epub 2014 Mar 27.
Biochem Biophys Res Commun. 2014.
PMID: 24680828
Free PMC article.
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