Miles DR - Search Results

1

Assessment of cabozantinib treatment on QT interval in a phase 3 study in medullary thyroid cancer: evaluation of indirect QT effects mediated through treatment-induced changes in serum electrolytes.

Miles DR, Lacy SA, Wada DR, Milwee S, Yaron Y, Nguyen LT. Miles DR, et al. Cancer Chemother Pharmacol. 2017 Aug;80(2):295-306. doi: 10.1007/s00280-017-3349-y. Epub 2017 Jun 20. Cancer Chemother Pharmacol. 2017. PMID: 28634649 Clinical Trial.

2

Pharmacokinetic (PK) drug interaction studies of cabozantinib: Effect of CYP3A inducer rifampin and inhibitor ketoconazole on cabozantinib plasma PK and effect of cabozantinib on CYP2C8 probe substrate rosiglitazone plasma PK.

Nguyen L, Holland J, Miles D, Engel C, Benrimoh N, O'Reilly T, Lacy S. Nguyen L, et al. J Clin Pharmacol. 2015 Sep;55(9):1012-23. doi: 10.1002/jcph.510. Epub 2015 Jun 2. J Clin Pharmacol. 2015. PMID: 25854986 Clinical Trial.

3

Metabolism and Disposition of Cabozantinib in Healthy Male Volunteers and Pharmacologic Characterization of Its Major Metabolites.

Lacy S, Hsu B, Miles D, Aftab D, Wang R, Nguyen L. Lacy S, et al. Drug Metab Dispos. 2015 Aug;43(8):1190-207. doi: 10.1124/dmd.115.063610. Epub 2015 May 26. Drug Metab Dispos. 2015. PMID: 26015560

4

Population Pharmacokinetic Model of Cabozantinib in Patients with Medullary Thyroid Carcinoma and Its Application to an Exposure-Response Analysis.

Miles D, Jumbe NL, Lacy S, Nguyen L. Miles D, et al. Clin Pharmacokinet. 2016 Jan;55(1):93-105. doi: 10.1007/s40262-015-0295-x. Clin Pharmacokinet. 2016. PMID: 26149244

5

Population pharmacokinetic/pharmacodynamic modeling of tumor growth kinetics in medullary thyroid cancer patients receiving cabozantinib.

Miles DR, Wada DR, Jumbe NL, Lacy SA, Nguyen LT. Miles DR, et al. Anticancer Drugs. 2016 Apr;27(4):328-41. doi: 10.1097/CAD.0000000000000330. Anticancer Drugs. 2016. PMID: 26825867

6

Clinical Pharmacokinetics and Pharmacodynamics of Cabozantinib.

Lacy SA, Miles DR, Nguyen LT. Lacy SA, et al. Among authors: miles dr. Clin Pharmacokinet. 2017 May;56(5):477-491. doi: 10.1007/s40262-016-0461-9. Clin Pharmacokinet. 2017. PMID: 27734291 Review.

7

A phase Ib/II study of cabozantinib (XL184) with or without erlotinib in patients with non-small cell lung cancer.

Wakelee HA, Gettinger S, Engelman J, Jänne PA, West H, Subramaniam DS, Leach J, Wax M, Yaron Y, Miles DR, Lara PN Jr. Wakelee HA, et al. Among authors: miles dr. Cancer Chemother Pharmacol. 2017 May;79(5):923-932. doi: 10.1007/s00280-017-3283-z. Epub 2017 Mar 28. Cancer Chemother Pharmacol. 2017. PMID: 28352985 Free PMC article. Clinical Trial.

8

Population exposure-response analysis of cabozantinib efficacy and safety endpoints in patients with renal cell carcinoma.

Lacy S, Nielsen J, Yang B, Miles D, Nguyen L, Hutmacher M. Lacy S, et al. Cancer Chemother Pharmacol. 2018 Jun;81(6):1061-1070. doi: 10.1007/s00280-018-3579-7. Epub 2018 Apr 17. Cancer Chemother Pharmacol. 2018. PMID: 29667066 Free PMC article. Clinical Trial.

9

A population pharmacokinetic model of cabozantinib in healthy volunteers and patients with various cancer types.

Lacy S, Yang B, Nielsen J, Miles D, Nguyen L, Hutmacher M. Lacy S, et al. Cancer Chemother Pharmacol. 2018 Jun;81(6):1071-1082. doi: 10.1007/s00280-018-3581-0. Epub 2018 Apr 23. Cancer Chemother Pharmacol. 2018. PMID: 29687244 Free PMC article.

10

A safety, tolerability, and pharmacokinetic analysis of two phase I studies of multitargeted small molecule tyrosine kinase inhibitor XL647 with an intermittent and continuous dosing schedule in patients with advanced solid malignancies.

Das M, Padda SK, Frymoyer A, Molina J, Adjei A, Lensing JL, Miles D, Sikic BI, Wakelee HA. Das M, et al. Cancer Chemother Pharmacol. 2018 Sep;82(3):541-550. doi: 10.1007/s00280-018-3646-0. Epub 2018 Jul 20. Cancer Chemother Pharmacol. 2018. PMID: 30030583 Clinical Trial.

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