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Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
Huang Y, Zhang J, Yu Z, Zhang H, Wang Y, Lingel A, Qi W, Gu J, Zhao K, Shultz MD, Wang L, Fu X, Sun Y, Zhang Q, Jiang X, Zhang J, Zhang C, Li L, Zeng J, Feng L, Zhang C, Liu Y, Zhang M, Zhang L, Zhao M, Gao Z, Liu X, Fang D, Guo H, Mi Y, Gabriel T, Dillon MP, Atadja P, Oyang C. Huang Y, et al. Among authors: zhang l, zhang m, zhang c, zhang q, zhang j, zhang h. J Med Chem. 2017 Mar 23;60(6):2215-2226. doi: 10.1021/acs.jmedchem.6b01576. Epub 2017 Feb 6. J Med Chem. 2017. PMID: 28092155
Effects of rigidity on the selectivity of protein kinase inhibitors.
Assadieskandar A, Yu C, Maisonneuve P, Liu X, Chen YC, Prakash GKS, Kurinov I, Sicheri F, Zhang C. Assadieskandar A, et al. Among authors: zhang c. Eur J Med Chem. 2018 Feb 25;146:519-528. doi: 10.1016/j.ejmech.2018.01.053. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29407977 Free PMC article.
Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases.
Assadieskandar A, Yu C, Maisonneuve P, Kurinov I, Sicheri F, Zhang C. Assadieskandar A, et al. Among authors: zhang c. ACS Med Chem Lett. 2019 Jun 4;10(7):1074-1080. doi: 10.1021/acsmedchemlett.9b00194. eCollection 2019 Jul 11. ACS Med Chem Lett. 2019. PMID: 31312411 Free PMC article.
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.
Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C, Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, Chiang DY, Chuai S, Cogan SM, Collins SD, Dammassa E, Ebel N, Embry M, Green J, Kauffmann A, Kowal C, Leary RJ, Lehar J, Liang Y, Loo A, Lorenzana E, Robert McDonald E 3rd, McLaughlin ME, Merkin J, Meyer R, Naylor TL, Patawaran M, Reddy A, Röelli C, Ruddy DA, Salangsang F, Santacroce F, Singh AP, Tang Y, Tinetto W, Tobler S, Velazquez R, Venkatesan K, Von Arx F, Wang HQ, Wang Z, Wiesmann M, Wyss D, Xu F, Bitter H, Atadja P, Lees E, Hofmann F, Li E, Keen N, Cozens R, Jensen MR, Pryer NK, Williams JA, Sellers WR. Gao H, et al. Among authors: zhang c, zhang y. Nat Med. 2015 Nov;21(11):1318-25. doi: 10.1038/nm.3954. Epub 2015 Oct 19. Nat Med. 2015. PMID: 26479923
Reactivity-based chemical-genetic study of protein kinases.
Rezende Miranda R, Zhang C. Rezende Miranda R, et al. Among authors: zhang c. RSC Med Chem. 2022 Mar 30;13(7):783-797. doi: 10.1039/d1md00389e. eCollection 2022 Jul 20. RSC Med Chem. 2022. PMID: 35923719 Free PMC article. Review.
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