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Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells.
Huels DJ, Bruens L, Hodder MC, Cammareri P, Campbell AD, Ridgway RA, Gay DM, Solar-Abboud M, Faller WJ, Nixon C, Zeiger LB, McLaughlin ME, Morrissey E, Winton DJ, Snippert HJ, van Rheenen J, Sansom OJ. Huels DJ, et al. Among authors: bruens l. Nat Commun. 2018 Mar 19;9(1):1132. doi: 10.1038/s41467-018-03426-2. Nat Commun. 2018. PMID: 29556067 Free PMC article.
Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer.
Fumagalli A, Oost KC, Kester L, Morgner J, Bornes L, Bruens L, Spaargaren L, Azkanaz M, Schelfhorst T, Beerling E, Heinz MC, Postrach D, Seinstra D, Sieuwerts AM, Martens JWM, van der Elst S, van Baalen M, Bhowmick D, Vrisekoop N, Ellenbroek SIJ, Suijkerbuijk SJE, Snippert HJ, van Rheenen J. Fumagalli A, et al. Among authors: bruens l. Cell Stem Cell. 2020 Apr 2;26(4):569-578.e7. doi: 10.1016/j.stem.2020.02.008. Epub 2020 Mar 12. Cell Stem Cell. 2020. PMID: 32169167 Free PMC article.
Retrograde movements determine effective stem cell numbers in the intestine.
Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo E, van Rheenen J. Azkanaz M, et al. Among authors: bruens l. Nature. 2022 Jul;607(7919):548-554. doi: 10.1038/s41586-022-04962-0. Epub 2022 Jul 13. Nature. 2022. PMID: 35831497 Free PMC article.
Capturing Stem Cell Behavior Using Intravital and Live Cell Microscopy.
Fumagalli A, Bruens L, Scheele CLGJ, van Rheenen J. Fumagalli A, et al. Among authors: bruens l. Cold Spring Harb Perspect Biol. 2020 Sep 1;12(9):a035949. doi: 10.1101/cshperspect.a035949. Cold Spring Harb Perspect Biol. 2020. PMID: 31767651 Free PMC article. Review.