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Tenecteplase versus alteplase for thrombolysis in patients selected by use of perfusion imaging within 4·5 h of onset of ischaemic stroke (TASTE): a multicentre, randomised, controlled, phase 3 non-inferiority trial.
Parsons MW, Yogendrakumar V, Churilov L, Garcia-Esperon C, Campbell BCV, Russell ML, Sharma G, Chen C, Lin L, Chew BL, Ng FC, Deepak A, Choi PMC, Kleinig TJ, Cordato DJ, Wu TY, Fink JN, Ma H, Phan TG, Markus HS, Molina CA, Tsai CH, Lee JT, Jeng JS, Strbian D, Meretoja A, Arenillas JF, Buck BH, Devlin MJ, Brown H, Butcher KS, O'Brien B, Sabet A, Wijeratne T, Bivard A, Grimley RS, Agarwal S, Munshi SK, Donnan GA, Davis SM, Miteff F, Spratt NJ, Levi CR; TASTE investigators. Parsons MW, et al. Lancet Neurol. 2024 Jun 13:S1474-4422(24)00206-0. doi: 10.1016/S1474-4422(24)00206-0. Online ahead of print. Lancet Neurol. 2024. PMID: 38880118
Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1.
Sabat M, Carney DW, Hernandez-Torres G, Gibson TS, Balakrishna D, Zou H, Xu R, Chen CH, de Jong R, Dougan DR, Qin L, Bigi-Botterill SV, Chambers A, Miura J, Johnson LK, Ermolieff J, Johns D, Selimkhanov J, Kwok L, DeMent K, Proffitt C, Vu P, Lindsey EA, Ivetac T, Jennings A, Wang H, Manam P, Santos C, Fullenwider C, Manohar R, Flick AC. Sabat M, et al. Among authors: chen ch. J Med Chem. 2024 Jun 13. doi: 10.1021/acs.jmedchem.4c00743. Online ahead of print. J Med Chem. 2024. PMID: 38872300
Cleavage of Hsp70.1 causes lysosomal cell death under stress conditions.
Yamashima T, Mochly-Rosen D, Wakatsuki S, Mizukoshi E, Seike T, Larus IM, Chen CH, Takemura M, Saito H, Ohashi A. Yamashima T, et al. Among authors: chen ch. Front Mol Biosci. 2024 May 27;11:1378656. doi: 10.3389/fmolb.2024.1378656. eCollection 2024. Front Mol Biosci. 2024. PMID: 38859931 Free PMC article. Review.
8,827 results