Janzen W - Search Results

1

A Novel Family of Small Molecules that Enhance the Intracellular Delivery and Pharmacological Effectiveness of Antisense and Splice Switching Oligonucleotides.

Wang L, Ariyarathna Y, Ming X, Yang B, James LI, Kreda SM, Porter M, Janzen W, Juliano RL. Wang L, et al. Among authors: janzen w. ACS Chem Biol. 2017 Aug 18;12(8):1999-2007. doi: 10.1021/acschembio.7b00242. Epub 2017 Jul 14. ACS Chem Biol. 2017. PMID: 28703575 Free PMC article.

2

High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides.

Yang B, Ming X, Cao C, Laing B, Yuan A, Porter MA, Hull-Ryde EA, Maddry J, Suto M, Janzen WP, Juliano RL. Yang B, et al. Among authors: janzen wp. Nucleic Acids Res. 2015 Feb 27;43(4):1987-96. doi: 10.1093/nar/gkv060. Epub 2015 Feb 6. Nucleic Acids Res. 2015. PMID: 25662226 Free PMC article.

3

Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.

Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, James LI, Frye SV. Perfetti MT, et al. ACS Chem Biol. 2015 Apr 17;10(4):1072-81. doi: 10.1021/cb500956g. Epub 2015 Jan 28. ACS Chem Biol. 2015. PMID: 25590533 Free PMC article.

4

Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.

James LI, Korboukh VK, Krichevsky L, Baughman BM, Herold JM, Norris JL, Jin J, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV. James LI, et al. J Med Chem. 2013 Sep 26;56(18):7358-71. doi: 10.1021/jm400919p. Epub 2013 Sep 16. J Med Chem. 2013. PMID: 24040942 Free PMC article.

5

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.

James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W, Marcon E, Guo H, Gao C, Huang XP, Duan S, Emili A, Greenblatt JF, Kireev DB, Jin J, Janzen WP, Brown PJ, Bedford MT, Arrowsmith CH, Frye SV. James LI, et al. Among authors: janzen wp. Nat Chem Biol. 2013 Mar;9(3):184-91. doi: 10.1038/nchembio.1157. Epub 2013 Jan 6. Nat Chem Biol. 2013. PMID: 23292653 Free PMC article.

6

Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε.

Hutti JE, Porter MA, Cheely AW, Cantley LC, Wang X, Kireev D, Baldwin AS, Janzen WP. Hutti JE, et al. Among authors: janzen wp. PLoS One. 2012;7(7):e41494. doi: 10.1371/journal.pone.0041494. Epub 2012 Jul 30. PLoS One. 2012. PMID: 22859992 Free PMC article.

7

Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen.

Hull-Ryde EA, Porter MA, Fowler KA, Kireev D, Li K, Simpson CD, Sassano MF, Suto MJ, Pearce KH, Janzen W, Coghill JM. Hull-Ryde EA, et al. Among authors: janzen w. SLAS Discov. 2018 Dec;23(10):1083-1091. doi: 10.1177/2472555218780917. Epub 2018 Jun 29. SLAS Discov. 2018. PMID: 29958052 Free article.

8

The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.

Camerino MA, Zhong N, Dong A, Dickson BM, James LI, Baughman BM, Norris JL, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV. Camerino MA, et al. Medchemcomm. 2013 Nov;4(11):1501-1507. doi: 10.1039/C3MD00197K. Medchemcomm. 2013. PMID: 24466405 Free PMC article.

9

Filtration improves the performance of a high-throughput screen for anti-mycobacterial compounds.

Cheng N, Porter MA, Frick LW, Nguyen Y, Hayden JD, Young EF, Braunstein MS, Hull-Ryde EA, Janzen WP. Cheng N, et al. Among authors: janzen wp. PLoS One. 2014 May 2;9(5):e96348. doi: 10.1371/journal.pone.0096348. eCollection 2014. PLoS One. 2014. PMID: 24788852 Free PMC article.

10

Screening technologies for small molecule discovery: the state of the art.

Janzen WP. Janzen WP. Chem Biol. 2014 Sep 18;21(9):1162-70. doi: 10.1016/j.chembiol.2014.07.015. Chem Biol. 2014. PMID: 25237860 Review.

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