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Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins.
Alves ML, Dias FAL, Gaffin RD, Simon JN, Montminy EM, Biesiadecki BJ, Hinken AC, Warren CM, Utter MS, Davis RT Rd, Sakthivel S, Robbins J, Wieczorek DF, Solaro RJ, Wolska BM. Alves ML, et al. Among authors: gaffin rd. Circ Cardiovasc Genet. 2014 Apr;7(2):132-143. doi: 10.1161/CIRCGENETICS.113.000324. Epub 2014 Feb 28. Circ Cardiovasc Genet. 2014. PMID: 24585742 Free PMC article.
Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy.
Peña JR, Szkudlarek AC, Warren CM, Heinrich LS, Gaffin RD, Jagatheesan G, del Monte F, Hajjar RJ, Goldspink PH, Solaro RJ, Wieczorek DF, Wolska BM. Peña JR, et al. Among authors: gaffin rd. J Mol Cell Cardiol. 2010 Dec;49(6):993-1002. doi: 10.1016/j.yjmcc.2010.09.010. Epub 2010 Sep 18. J Mol Cell Cardiol. 2010. PMID: 20854827 Free PMC article.
Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics.
Gaffin RD, Gokulan K, Sacchettini JC, Hewett TE, Klevitsky R, Robbins J, Sarin V, Zawieja DC, Meininger GA, Muthuchamy M. Gaffin RD, et al. Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H552-63. doi: 10.1152/ajpheart.00688.2005. Epub 2006 Feb 24. Am J Physiol Heart Circ Physiol. 2006. PMID: 16501024 Free article.
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