Arnst KE - Search Results

1

Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy.

Chen H, Lin Z, Arnst KE, Miller DD, Li W. Chen H, et al. Among authors: arnst ke. Molecules. 2017 Aug 1;22(8):1281. doi: 10.3390/molecules22081281. Molecules. 2017. PMID: 28763044 Free PMC article. Review.

2

Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy.

Arnst KE, Banerjee S, Chen H, Deng S, Hwang DJ, Li W, Miller DD. Arnst KE, et al. Med Res Rev. 2019 Jul;39(4):1398-1426. doi: 10.1002/med.21568. Epub 2019 Feb 11. Med Res Rev. 2019. PMID: 30746734 Free PMC article. Review.

3

A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance.

Arnst KE, Wang Y, Hwang DJ, Xue Y, Costello T, Hamilton D, Chen Q, Yang J, Park F, Dalton JT, Miller DD, Li W. Arnst KE, et al. Cancer Res. 2018 Jan 1;78(1):265-277. doi: 10.1158/0008-5472.CAN-17-0577. Epub 2017 Nov 27. Cancer Res. 2018. PMID: 29180476

4

Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.

Banerjee S, Arnst KE, Wang Y, Kumar G, Deng S, Yang L, Li GB, Yang J, White SW, Li W, Miller DD. Banerjee S, et al. Among authors: arnst ke. J Med Chem. 2018 Feb 22;61(4):1704-1718. doi: 10.1021/acs.jmedchem.7b01858. Epub 2018 Feb 12. J Med Chem. 2018. PMID: 29406710 Free PMC article.

5

Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors.

Wang Q, Arnst KE, Xue Y, Lei ZN, Ma D, Chen ZS, Miller DD, Li W. Wang Q, et al. Among authors: arnst ke. Eur J Med Chem. 2018 Apr 10;149:211-224. doi: 10.1016/j.ejmech.2018.02.045. Epub 2018 Feb 19. Eur J Med Chem. 2018. PMID: 29501942 Free PMC article.

6

Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities.

Wang Q, Arnst KE, Wang Y, Kumar G, Ma D, Chen H, Wu Z, Yang J, White SW, Miller DD, Li W. Wang Q, et al. Among authors: arnst ke. J Med Chem. 2018 Sep 13;61(17):7877-7891. doi: 10.1021/acs.jmedchem.8b00827. Epub 2018 Aug 30. J Med Chem. 2018. PMID: 30122035 Free PMC article.

7

Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.

Arnst KE, Wang Y, Lei ZN, Hwang DJ, Kumar G, Ma D, Parke DN, Chen Q, Yang J, White SW, Seagroves TN, Chen ZS, Miller DD, Li W. Arnst KE, et al. Mol Pharmacol. 2019 Jul;96(1):73-89. doi: 10.1124/mol.118.114801. Epub 2019 May 1. Mol Pharmacol. 2019. PMID: 31043459 Free PMC article.

8

Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.

Wang Q, Arnst KE, Wang Y, Kumar G, Ma D, White SW, Miller DD, Li W, Li W. Wang Q, et al. Among authors: arnst ke. J Med Chem. 2019 Jul 25;62(14):6734-6750. doi: 10.1021/acs.jmedchem.9b00706. Epub 2019 Jul 12. J Med Chem. 2019. PMID: 31251599

9

X-ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors.

Arnst KE, Banerjee S, Wang Y, Chen H, Li Y, Yang L, Li W, Miller DD, Li W. Arnst KE, et al. ACS Chem Biol. 2019 Dec 20;14(12):2810-2821. doi: 10.1021/acschembio.9b00696. Epub 2019 Nov 25. ACS Chem Biol. 2019. PMID: 31714738

10

X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.

Banerjee S, Mahmud F, Deng S, Ma L, Yun MK, Fakayode SO, Arnst KE, Yang L, Chen H, Wu Z, Lukka PB, Parmar K, Meibohm B, White SW, Wang Y, Li W, Miller DD. Banerjee S, et al. Among authors: arnst ke. J Med Chem. 2021 Sep 9;64(17):13072-13095. doi: 10.1021/acs.jmedchem.1c01202. Epub 2021 Aug 18. J Med Chem. 2021. PMID: 34406768 Free PMC article.

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