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Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Liang J, Van Abbema A, Balazs M, Barrett K, Berezhkovsky L, Blair WS, Chang C, Delarosa D, DeVoss J, Driscoll J, Eigenbrot C, Goodacre S, Ghilardi N, MacLeod C, Johnson A, Bir Kohli P, Lai Y, Lin Z, Mantik P, Menghrajani K, Nguyen H, Peng I, Sambrone A, Shia S, Smith J, Sohn S, Tsui V, Ultsch M, Williams K, Wu LC, Yang W, Zhang B, Magnuson S. Liang J, et al. Among authors: nguyen h. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4370-4376. doi: 10.1016/j.bmcl.2017.08.022. Epub 2017 Aug 12. Bioorg Med Chem Lett. 2017. PMID: 28830649
A faster-acting and more potent form of tissue plasminogen activator.
Keyt BA, Paoni NF, Refino CJ, Berleau L, Nguyen H, Chow A, Lai J, Peña L, Pater C, Ogez J, et al. Keyt BA, et al. Among authors: nguyen h. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3670-4. doi: 10.1073/pnas.91.9.3670. Proc Natl Acad Sci U S A. 1994. PMID: 8170967 Free PMC article.
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