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IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement.
van Dam AD, van Beek L, Pronk ACM, van den Berg SM, Van den Bossche J, de Winther MPJ, Koning F, van Kooten C, Rensen PCN, Boon MR, Verbeek JS, van Dijk KW, van Harmelen V. van Dam AD, et al. Among authors: de winther mpj. Int J Obes (Lond). 2018 Feb;42(2):260-269. doi: 10.1038/ijo.2017.209. Epub 2017 Aug 30. Int J Obes (Lond). 2018. PMID: 28852207
Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages.
de Winther MP, van Dijk KW, van Vlijmen BJ, Gijbels MJ, Heus JJ, Wijers ER, van den Bos AC, Breuer M, Frants RR, Havekes LM, Hofker MH. de Winther MP, et al. Atherosclerosis. 1999 Dec;147(2):339-47. doi: 10.1016/s0021-9150(99)00204-x. Atherosclerosis. 1999. PMID: 10559520
BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality.
Boon MR, van den Berg SA, Wang Y, van den Bossche J, Karkampouna S, Bauwens M, De Saint-Hubert M, van der Horst G, Vukicevic S, de Winther MP, Havekes LM, Jukema JW, Tamsma JT, van der Pluijm G, van Dijk KW, Rensen PC. Boon MR, et al. PLoS One. 2013 Sep 16;8(9):e74083. doi: 10.1371/journal.pone.0074083. eCollection 2013. PLoS One. 2013. PMID: 24066098 Free PMC article.
Macrophage polarization: the epigenetic point of view.
Van den Bossche J, Neele AE, Hoeksema MA, de Winther MP. Van den Bossche J, et al. Curr Opin Lipidol. 2014 Oct;25(5):367-73. doi: 10.1097/MOL.0000000000000109. Curr Opin Lipidol. 2014. PMID: 25188918 Review.
Inhibiting epigenetic enzymes to improve atherogenic macrophage functions.
Van den Bossche J, Neele AE, Hoeksema MA, de Heij F, Boshuizen MC, van der Velden S, de Boer VC, Reedquist KA, de Winther MP. Van den Bossche J, et al. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):396-402. doi: 10.1016/j.bbrc.2014.11.029. Epub 2014 Nov 18. Biochem Biophys Res Commun. 2014. PMID: 25446073
198 results