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The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin.
Biochem Biophys Res Commun. 2017 Oct 21;492(3):331-337. doi: 10.1016/j.bbrc.2017.08.113. Epub 2017 Aug 30.
Biochem Biophys Res Commun. 2017.
PMID: 28859985
Free PMC article.
Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers.
Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bähr A, Klymiuk N, Wine JJ, Koeck PJB, Thornton DJ, Hebert H, Hansson GC.
Trillo-Muyo S, et al. Among authors: meiss ln.
J Biol Chem. 2018 Apr 13;293(15):5746-5754. doi: 10.1074/jbc.RA117.001014. Epub 2018 Feb 13.
J Biol Chem. 2018.
PMID: 29440393
Free PMC article.
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The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation.
Ermund A, Meiss LN, Dolan B, Bähr A, Klymiuk N, Hansson GC.
Ermund A, et al. Among authors: meiss ln.
Eur Respir J. 2018 Aug 30;52(2):1800457. doi: 10.1183/13993003.00457-2018. Print 2018 Aug.
Eur Respir J. 2018.
PMID: 29853489
Free PMC article.
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Mucus threads from surface goblet cells clear particles from the airways.
Ermund A, Meiss LN, Dolan B, Jaudas F, Ewaldsson L, Bähr A, Klymiuk N, Hansson GC.
Ermund A, et al. Among authors: meiss ln.
Respir Res. 2021 Nov 25;22(1):303. doi: 10.1186/s12931-021-01898-3.
Respir Res. 2021.
PMID: 34823518
Free PMC article.
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Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus.
Ermund A, Meiss LN, Gustafsson JK, Hansson GC.
Ermund A, et al. Among authors: meiss ln.
Eur J Pharmacol. 2015 Oct 5;764:109-117. doi: 10.1016/j.ejphar.2015.06.051. Epub 2015 Jun 30.
Eur J Pharmacol. 2015.
PMID: 26134505
Free PMC article.
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Hypertonic saline releases the attached small intestinal cystic fibrosis mucus.
Ermund A, Meiss LN, Scholte BJ, Hansson GC.
Ermund A, et al. Among authors: meiss ln.
Clin Exp Pharmacol Physiol. 2015 Jan;42(1):69-75. doi: 10.1111/1440-1681.12322.
Clin Exp Pharmacol Physiol. 2015.
PMID: 25311799
Free PMC article.
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OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating calcium.
Ermund A, Recktenwald CV, Skjåk-Braek G, Meiss LN, Onsøyen E, Rye PD, Dessen A, Myrset AH, Hansson GC.
Ermund A, et al. Among authors: meiss ln.
Clin Exp Pharmacol Physiol. 2017 Jun;44(6):639-647. doi: 10.1111/1440-1681.12744.
Clin Exp Pharmacol Physiol. 2017.
PMID: 28261854
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Family Planning and Reproductive Health in Cystic Fibrosis.
Meiss LN, Jain R, Kazmerski TM.
Meiss LN, et al.
Clin Chest Med. 2022 Dec;43(4):811-820. doi: 10.1016/j.ccm.2022.06.015.
Clin Chest Med. 2022.
PMID: 36344082
Review.
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