Caplen N - Search Results

1

BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1).

Pongas G, Kim MK, Min DJ, House CD, Jordan E, Caplen N, Chakka S, Ohiri J, Kruhlak MJ, Annunziata CM. Pongas G, et al. Among authors: caplen n. Oncotarget. 2017 May 3;8(31):51402-51415. doi: 10.18632/oncotarget.17572. eCollection 2017 Aug 1. Oncotarget. 2017. PMID: 28881656 Free PMC article.

2

Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activity.

Ou O, Huppi K, Chakka S, Gehlhaus K, Dubois W, Patel J, Chen J, Mackiewicz M, Jones TL, Pitt JJ, Martin SE, Goldsmith P, Simmons JK, Mock BA, Caplen NJ. Ou O, et al. Cancer Lett. 2014 Nov 28;354(2):336-47. doi: 10.1016/j.canlet.2014.08.043. Epub 2014 Sep 1. Cancer Lett. 2014. PMID: 25193464 Free PMC article.

3

Selective targeting of KRAS-mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-mutant cells.

Hara T, Jones MF, Subramanian M, Li XL, Ou O, Zhu Y, Yang Y, Wakefield LM, Hussain SP, Gaedcke J, Ried T, Luo J, Caplen NJ, Lal A. Hara T, et al. Oncotarget. 2014 Sep 15;5(17):7635-50. doi: 10.18632/oncotarget.2284. Oncotarget. 2014. PMID: 25245095 Free PMC article.

4

Identification of therapeutic targets applicable to clinical strategies in ovarian cancer.

Kim MK, Caplen N, Chakka S, Hernandez L, House C, Pongas G, Jordan E, Annunziata CM. Kim MK, et al. Among authors: caplen n. BMC Cancer. 2016 Aug 24;16(1):678. doi: 10.1186/s12885-016-2675-5. BMC Cancer. 2016. PMID: 27558154 Free PMC article.

5

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival.

Lee CS, Lee LC, Yuan TL, Chakka S, Fellmann C, Lowe SW, Caplen NJ, McCormick F, Luo J. Lee CS, et al. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4508-4517. doi: 10.1073/pnas.1817494116. Epub 2019 Feb 1. Proc Natl Acad Sci U S A. 2019. PMID: 30709910 Free PMC article.

6

Endogenous EWSR1 Exists in Two Visual Modalities That Reflect Its Associations with Nucleic Acids and Concentration at Sites of Active Transcription.

Sundara Rajan S, Ebegboni VJ, Pichling P, Ludwig KR, Jones TL, Chari R, Tran A, Kruhlak MJ, Loncarek J, Caplen NJ. Sundara Rajan S, et al. Among authors: caplen nj. Mol Cell Biol. 2024;44(3):103-122. doi: 10.1080/10985549.2024.2315425. Epub 2024 Mar 20. Mol Cell Biol. 2024. PMID: 38506112

7

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response.

Zhang YW, Jones TL, Martin SE, Caplen NJ, Pommier Y. Zhang YW, et al. J Biol Chem. 2009 Jul 3;284(27):18085-95. doi: 10.1074/jbc.M109.003020. Epub 2009 May 5. J Biol Chem. 2009. PMID: 19416980 Free PMC article.

8

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.

Garimella SV, Gehlhaus K, Dine JL, Pitt JJ, Grandin M, Chakka S, Nau MM, Caplen NJ, Lipkowitz S. Garimella SV, et al. Breast Cancer Res. 2014 Apr 17;16(2):R41. doi: 10.1186/bcr3645. Breast Cancer Res. 2014. PMID: 24745479 Free PMC article.

9

Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins.

Maachani UB, Kramp T, Hanson R, Zhao S, Celiku O, Shankavaram U, Colombo R, Caplen NJ, Camphausen K, Tandle A. Maachani UB, et al. Mol Cancer Res. 2015 May;13(5):852-62. doi: 10.1158/1541-7786.MCR-14-0462-T. Epub 2015 Feb 26. Mol Cancer Res. 2015. PMID: 25722303 Free PMC article.

10

Enhancing standard of care chemotherapy efficacy using DNA-dependent protein kinase (DNA-PK) inhibition in preclinical models of Ewing sarcoma.

Collins VJ, Ludwig KR, Nelson AE, Sundara Rajan S, Yeung C, Vulikh K, Isanogle KA, Mendoza A, Difilippantonio S, Karim BO, Caplen NJ, Heske CM. Collins VJ, et al. Among authors: caplen nj. Mol Cancer Ther. 2024 Apr 24. doi: 10.1158/1535-7163.MCT-23-0641. Online ahead of print. Mol Cancer Ther. 2024. PMID: 38657228

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