Kostenis E - Search Results

1

Targeted inhibition of G_q signaling induces airway relaxation in mouse models of asthma.

Matthey M, Roberts R, Seidinger A, Simon A, Schröder R, Kuschak M, Annala S, König GM, Müller CE, Hall IP, Kostenis E, Fleischmann BK, Wenzel D. Matthey M, et al. Among authors: kostenis e. Sci Transl Med. 2017 Sep 13;9(407):eaag2288. doi: 10.1126/scitranslmed.aag2288. Sci Transl Med. 2017. PMID: 28904224

2

The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.

Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E. Schröder R, et al. Among authors: kostenis e. J Biol Chem. 2009 Jan 9;284(2):1324-36. doi: 10.1074/jbc.M806867200. Epub 2008 Nov 14. J Biol Chem. 2009. PMID: 19010788 Free article.

3

Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling.

Hillmann P, Ko GY, Spinrath A, Raulf A, von Kügelgen I, Wolff SC, Nicholas RA, Kostenis E, Höltje HD, Müller CE. Hillmann P, et al. Among authors: kostenis e. J Med Chem. 2009 May 14;52(9):2762-75. doi: 10.1021/jm801442p. J Med Chem. 2009. PMID: 19419204

4

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.

Schröder R, Janssen N, Schmidt J, Kebig A, Merten N, Hennen S, Müller A, Blättermann S, Mohr-Andrä M, Zahn S, Wenzel J, Smith NJ, Gomeza J, Drewke C, Milligan G, Mohr K, Kostenis E. Schröder R, et al. Among authors: kostenis e. Nat Biotechnol. 2010 Sep;28(9):943-9. doi: 10.1038/nbt.1671. Epub 2010 Aug 15. Nat Biotechnol. 2010. PMID: 20711173 Free article.

5

D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on T(H)2 cells.

Sedej M, Schröder R, Bell K, Platzer W, Vukoja A, Kostenis E, Heinemann A, Waldhoer M. Sedej M, et al. Among authors: kostenis e. J Allergy Clin Immunol. 2012 Feb;129(2):492-500, 500.e1-9. doi: 10.1016/j.jaci.2011.08.015. Epub 2011 Sep 17. J Allergy Clin Immunol. 2012. PMID: 21930295

6

Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells.

Schröder R, Schmidt J, Blättermann S, Peters L, Janssen N, Grundmann M, Seemann W, Kaufel D, Merten N, Drewke C, Gomeza J, Milligan G, Mohr K, Kostenis E. Schröder R, et al. Among authors: kostenis e. Nat Protoc. 2011 Oct 20;6(11):1748-60. doi: 10.1038/nprot.2011.386. Nat Protoc. 2011. PMID: 22015845

7

PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.

Schröder R, Xue L, Konya V, Martini L, Kampitsch N, Whistler JL, Ulven T, Heinemann A, Pettipher R, Kostenis E. Schröder R, et al. Among authors: kostenis e. PLoS One. 2012;7(3):e33329. doi: 10.1371/journal.pone.0033329. Epub 2012 Mar 19. PLoS One. 2012. PMID: 22442685 Free PMC article. Clinical Trial.

8

A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.

Blättermann S, Peters L, Ottersbach PA, Bock A, Konya V, Weaver CD, Gonzalez A, Schröder R, Tyagi R, Luschnig P, Gäb J, Hennen S, Ulven T, Pardo L, Mohr K, Gütschow M, Heinemann A, Kostenis E. Blättermann S, et al. Among authors: kostenis e. Nat Chem Biol. 2012 Jul;8(7):631-8. doi: 10.1038/nchembio.962. Epub 2012 May 27. Nat Chem Biol. 2012. PMID: 22634634

9

Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.

Hennen S, Wang H, Peters L, Merten N, Simon K, Spinrath A, Blättermann S, Akkari R, Schrage R, Schröder R, Schulz D, Vermeiren C, Zimmermann K, Kehraus S, Drewke C, Pfeifer A, König GM, Mohr K, Gillard M, Müller CE, Lu QR, Gomeza J, Kostenis E. Hennen S, et al. Among authors: kostenis e. Sci Signal. 2013 Oct 22;6(298):ra93. doi: 10.1126/scisignal.2004350. Sci Signal. 2013. PMID: 24150254 Free PMC article.

10

β-arrestin 2 inhibits proinflammatory chemokine production and attenuates contact allergic inflammation in the skin.

Gaffal E, Jakobs M, Glodde N, Schröder R, Kostenis E, Tüting T. Gaffal E, et al. Among authors: kostenis e. J Invest Dermatol. 2014 Aug;134(8):2131-2137. doi: 10.1038/jid.2014.117. Epub 2014 Feb 27. J Invest Dermatol. 2014. PMID: 24577407 Free article.

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