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Risk factors for thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype.
Broekman MMTJ, Coenen MJH, Wanten GJ, van Marrewijk CJ, Klungel OH, Verbeek ALM, Hooymans PM, Guchelaar HJ, Scheffer H, Derijks LJJ, Wong DR, de Jong DJ. Broekman MMTJ, et al. Aliment Pharmacol Ther. 2017 Nov;46(10):953-963. doi: 10.1111/apt.14323. Epub 2017 Sep 15. Aliment Pharmacol Ther. 2017. PMID: 28914446 Free PMC article. Clinical Trial.
The glutathione transferase Mu null genotype leads to lower 6-MMPR levels in patients treated with azathioprine but not with mercaptopurine.
Broekman MMTJ, Wong DR, Wanten GJA, Roelofs HM, van Marrewijk CJ, Klungel OH, Verbeek ALM, Hooymans PM, Guchelaar HJ, Scheffer H, Derijks LJJ, Coenen MJH, de Jong DJ. Broekman MMTJ, et al. Pharmacogenomics J. 2018 Jan;18(1):160-166. doi: 10.1038/tpj.2016.87. Epub 2017 Jan 3. Pharmacogenomics J. 2018. PMID: 28045129
More Dose-dependent Side Effects with Mercaptopurine over Azathioprine in IBD Treatment Due to Relatively Higher Dosing.
Broekman MMTJ, Coenen MJH, van Marrewijk CJ, Wanten GJA, Wong DR, Verbeek ALM, Klungel OH, Hooymans PM, Guchelaar HJ, Scheffer H, Derijks LJJ, de Jong DJ; TOPIC Recruitment Team. Broekman MMTJ, et al. Inflamm Bowel Dis. 2017 Oct;23(10):1873-1881. doi: 10.1097/MIB.0000000000001163. Inflamm Bowel Dis. 2017. PMID: 28644183 Free PMC article. Clinical Trial.
Patients' beliefs about medicine are associated with early thiopurine discontinuation in patients with inflammatory bowel diseases.
Broekman MMTJ, Coenen MJH, Wanten GJ, van Marrewijk CJ, Kievit W, Klungel OH, Verbeek ALM, Wong DR, Hooymans PM, Guchelaar HJ, Scheffer H, Derijks LJJ, Bouvy ML, de Jong DJ. Broekman MMTJ, et al. Eur J Gastroenterol Hepatol. 2018 Feb;30(2):167-173. doi: 10.1097/MEG.0000000000001025. Eur J Gastroenterol Hepatol. 2018. PMID: 29120908 Free PMC article. Clinical Trial.
Risk factors for rectal stump cancer in inflammatory bowel disease.
Lutgens MW, van Oijen MG, Vleggaar FP, Siersema PD, Broekman MM, Oldenburg B; Dutch Initiative on Crohn and Colitis. Lutgens MW, et al. Dis Colon Rectum. 2012 Feb;55(2):191-6. doi: 10.1097/DCR.0b013e31823b537c. Dis Colon Rectum. 2012. PMID: 22228163
17 results