Mustafa N - Search Results

1

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat.

Yao L, Mustafa N, Tan EC, Poulsen A, Singh P, Duong-Thi MD, Lee JXT, Ramanujulu PM, Chng WJ, Yen JJY, Ohlson S, Dymock BW. Yao L, et al. Among authors: mustafa n. J Med Chem. 2017 Oct 26;60(20):8336-8357. doi: 10.1021/acs.jmedchem.7b00678. Epub 2017 Oct 10. J Med Chem. 2017. PMID: 28953386

2

VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.

Hart S, Novotny-Diermayr V, Goh KC, Williams M, Tan YC, Ong LC, Cheong A, Ng BK, Amalini C, Madan B, Nagaraj H, Jayaraman R, Pasha KM, Ethirajulu K, Chng WJ, Mustafa N, Goh BC, Benes C, McDermott U, Garnett M, Dymock B, Wood JM. Hart S, et al. Among authors: mustafa n. Mol Cancer Ther. 2013 Feb;12(2):151-61. doi: 10.1158/1535-7163.MCT-12-0466. Epub 2012 Dec 27. Mol Cancer Ther. 2013. PMID: 23270925 Free PMC article.

3

MMSET regulates expression of IRF4 in t(4;14) myeloma and its silencing potentiates the effect of bortezomib.

Xie Z, Bi C, Chooi JY, Chan ZL, Mustafa N, Chng WJ. Xie Z, et al. Among authors: mustafa n. Leukemia. 2015 Dec;29(12):2347-54. doi: 10.1038/leu.2015.169. Epub 2015 Jun 30. Leukemia. 2015. PMID: 26196464

4

Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.

Yang EG, Mustafa N, Tan EC, Poulsen A, Ramanujulu PM, Chng WJ, Yen JJ, Dymock BW. Yang EG, et al. Among authors: mustafa n. J Med Chem. 2016 Sep 22;59(18):8233-62. doi: 10.1021/acs.jmedchem.6b00157. Epub 2016 Sep 8. J Med Chem. 2016. PMID: 27541357

5

VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim.

Mustafa N, Ting Lee JX, Adina Nee HF, Bi C, Chung TH, Hart S, Chng WJ. Mustafa N, et al. Oncotarget. 2017 Oct 20;8(60):101847-101864. doi: 10.18632/oncotarget.21988. eCollection 2017 Nov 24. Oncotarget. 2017. PMID: 29254208 Free PMC article.

6

Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma.

Shanmugam MK, Ahn KS, Lee JH, Kannaiyan R, Mustafa N, Manu KA, Siveen KS, Sethi G, Chng WJ, Kumar AP. Shanmugam MK, et al. Among authors: mustafa n. Front Pharmacol. 2018 May 3;9:365. doi: 10.3389/fphar.2018.00365. eCollection 2018. Front Pharmacol. 2018. PMID: 29773987 Free PMC article.

7

Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat.

Chu-Farseeva YY, Mustafa N, Poulsen A, Tan EC, Yen JJY, Chng WJ, Dymock BW. Chu-Farseeva YY, et al. Among authors: mustafa n. Eur J Med Chem. 2018 Oct 5;158:593-619. doi: 10.1016/j.ejmech.2018.09.024. Epub 2018 Sep 11. Eur J Med Chem. 2018. PMID: 30243158

8

Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.

Soumyanarayanan U, Ramanujulu PM, Mustafa N, Haider S, Fang Nee AH, Tong JX, Tan KSW, Chng WJ, Dymock BW. Soumyanarayanan U, et al. Among authors: mustafa n. Eur J Med Chem. 2019 Dec 15;184:111755. doi: 10.1016/j.ejmech.2019.111755. Epub 2019 Oct 7. Eur J Med Chem. 2019. PMID: 31627059

9

Determinants of response to daratumumab in Epstein-Barr virus-positive natural killer and T-cell lymphoma.

Mustafa N, Nee AHF, Chooi JY, Toh SHM, Chung TH, Selvarajan V, Fan S, Ng SB, Poon M, Chan E, Lee J, Chee YL, Jeyasekharan AD, Zhou L, Yang J, Chng WJ. Mustafa N, et al. J Immunother Cancer. 2021 Jul;9(7):e002123. doi: 10.1136/jitc-2020-002123. J Immunother Cancer. 2021. PMID: 34215687 Free PMC article.

10

T and NK cell lymphoma cell lines do not rely on ZAP-70 for survival.

de Mel S, Mustafa N, Selvarajan V, Azaman MI, Jaynes PW, Venguidessane S, Phuong HM, Alnaseri ZT, Phyu T, Girard LP, Chng WJ, Wardyn J, Li Y, An O, Yang H, Ng SB, Jeyasekharan AD. de Mel S, et al. Among authors: mustafa n. PLoS One. 2022 Jan 25;17(1):e0261469. doi: 10.1371/journal.pone.0261469. eCollection 2022. PLoS One. 2022. PMID: 35077445 Free PMC article.

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