van Berkel TJC - Search Results

1

Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression.

Willoughby JLS, Chan A, Sehgal A, Butler JS, Nair JK, Racie T, Shulga-Morskaya S, Nguyen T, Qian K, Yucius K, Charisse K, van Berkel TJC, Manoharan M, Rajeev KG, Maier MA, Jadhav V, Zimmermann TS. Willoughby JLS, et al. Among authors: van berkel tjc. Mol Ther. 2018 Jan 3;26(1):105-114. doi: 10.1016/j.ymthe.2017.08.019. Epub 2017 Sep 7. Mol Ther. 2018. PMID: 28988716 Free PMC article.

2

Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.

Nair JK, Willoughby JL, Chan A, Charisse K, Alam MR, Wang Q, Hoekstra M, Kandasamy P, Kel'in AV, Milstein S, Taneja N, O'Shea J, Shaikh S, Zhang L, van der Sluis RJ, Jung ME, Akinc A, Hutabarat R, Kuchimanchi S, Fitzgerald K, Zimmermann T, van Berkel TJ, Maier MA, Rajeev KG, Manoharan M. Nair JK, et al. J Am Chem Soc. 2014 Dec 10;136(49):16958-61. doi: 10.1021/ja505986a. Epub 2014 Dec 1. J Am Chem Soc. 2014. PMID: 25434769

3

bis-Cholesteryl-conjugated phosphorothioate oligodeoxynucleotides are highly selectively taken up by the liver.

Bijsterbosch MK, Manoharan M, Dorland R, Van Veghel R, Biessen EA, Van Berkel TJ. Bijsterbosch MK, et al. J Pharmacol Exp Ther. 2002 Aug;302(2):619-26. doi: 10.1124/jpet.302.2.619. J Pharmacol Exp Ther. 2002. PMID: 12130724

4

Selection of antisense oligodeoxynucleotides against glutathione S-transferase Mu.

't Hoen PA, Out R, Commandeur JN, Vermeulen NP, van Batenburg FH, Manoharan M, van Berkel TJ, Biessen EA, Bijsterbosch MK. 't Hoen PA, et al. RNA. 2002 Dec;8(12):1572-83. RNA. 2002. PMID: 12515389 Free PMC article.

5

Delivery of cholesteryl-conjugated phosphorothioate oligodeoxynucleotides to Kupffer cells by lactosylated low-density lipoprotein.

Bijsterbosch MK, Manoharan M, Dorland R, Waarlo IH, Biessen EA, van Berkel TJ. Bijsterbosch MK, et al. Biochem Pharmacol. 2001 Sep 1;62(5):627-33. doi: 10.1016/s0006-2952(01)00705-5. Biochem Pharmacol. 2001. PMID: 11585059

6

Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression.

't Hoen PA, Rosema BS, Commandeur JN, Vermeulen NP, Manoharan M, van Berkel TJ, Biessen EA, Bijsterbosch MK. 't Hoen PA, et al. Eur J Biochem. 2002 May;269(10):2574-83. doi: 10.1046/j.1432-1033.2002.02924.x. Eur J Biochem. 2002. PMID: 12027896 Free article.

7

Modification of the plasma clearance and liver uptake of steroid ester-conjugated oligodeoxynucleotides by association with (lactosylated) low-density lipoprotein.

Rump ET, de Vrueh RL, Manoharan M, Waarlo IH, van Veghel R, Biessen EA, van Berkel TJ, Bijsterbosch MK. Rump ET, et al. Biochem Pharmacol. 2000 Jun 1;59(11):1407-16. doi: 10.1016/s0006-2952(00)00243-4. Biochem Pharmacol. 2000. PMID: 10751550

8

In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.

Bijsterbosch MK, Manoharan M, Rump ET, De Vrueh RL, van Veghel R, Tivel KL, Biessen EA, Bennett CF, Cook PD, van Berkel TJ. Bijsterbosch MK, et al. Nucleic Acids Res. 1997 Aug 15;25(16):3290-6. doi: 10.1093/nar/25.16.3290. Nucleic Acids Res. 1997. PMID: 9241243 Free PMC article.

9

Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation.

Bijsterbosch MK, Rump ET, De Vrueh RL, Dorland R, van Veghel R, Tivel KL, Biessen EA, van Berkel TJ, Manoharan M. Bijsterbosch MK, et al. Nucleic Acids Res. 2000 Jul 15;28(14):2717-25. doi: 10.1093/nar/28.14.2717. Nucleic Acids Res. 2000. PMID: 10908328 Free PMC article.

10

Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo.

Rensen PC, Sliedregt LA, Ferns M, Kieviet E, van Rossenberg SM, van Leeuwen SH, van Berkel TJ, Biessen EA. Rensen PC, et al. J Biol Chem. 2001 Oct 5;276(40):37577-84. doi: 10.1074/jbc.M101786200. Epub 2001 Jul 30. J Biol Chem. 2001. PMID: 11479285 Free article.

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